Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 4924535..4925040 Replicon chromosome
Accession NZ_CP087177
Organism Pseudomonas moraviensis strain B21-039

Toxin (Protein)


Gene name relE Uniprot ID A0A2U1R9I4
Locus tag LOY57_RS21490 Protein ID WP_042608353.1
Coordinates 4924786..4925040 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1N7ATY6
Locus tag LOY57_RS21485 Protein ID WP_042608352.1
Coordinates 4924535..4924789 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY57_RS21460 (LOY57_21415) 4920216..4920545 + 330 WP_042608348.1 hypothetical protein -
LOY57_RS21465 (LOY57_21420) 4920564..4920932 - 369 WP_039761415.1 PH domain-containing protein -
LOY57_RS21470 (LOY57_21425) 4921096..4921467 + 372 WP_065616631.1 hypothetical protein -
LOY57_RS21475 (LOY57_21430) 4921560..4922312 + 753 WP_258639122.1 hypothetical protein -
LOY57_RS21480 (LOY57_21435) 4922383..4924302 + 1920 WP_258639124.1 alkaline phosphatase D family protein -
LOY57_RS21485 (LOY57_21440) 4924535..4924789 + 255 WP_042608352.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOY57_RS21490 (LOY57_21445) 4924786..4925040 + 255 WP_042608353.1 Txe/YoeB family addiction module toxin Toxin
LOY57_RS21495 (LOY57_21450) 4925034..4926221 - 1188 WP_258639126.1 aspartate aminotransferase family protein -
LOY57_RS21500 (LOY57_21455) 4926324..4927244 + 921 WP_042608355.1 LysR family transcriptional regulator -
LOY57_RS21505 (LOY57_21460) 4927284..4927688 + 405 WP_258639127.1 GNAT family N-acetyltransferase -
LOY57_RS21510 (LOY57_21465) 4927822..4928523 + 702 WP_258639129.1 hypothetical protein -
LOY57_RS21515 (LOY57_21470) 4928780..4929271 - 492 WP_016773306.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9967.53 Da        Isoelectric Point: 9.0627

>T225016 WP_042608353.1 NZ_CP087177:4924786-4925040 [Pseudomonas moraviensis]
MKIEFTPTGWEDYLWFQQNDKAGLKRINLLIKAIKREPFEGVGKPEALKHNMSGLWSRRVTAEHRLVYRVEDGEICVISC
RYHY

Download         Length: 255 bp

>T225016 NZ_CP120837:c2443857-2443702 [Salmonella enterica subsp. enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9503.96 Da        Isoelectric Point: 7.0130

>AT225016 WP_042608352.1 NZ_CP087177:4924535-4924789 [Pseudomonas moraviensis]
MQTINYTTARAHLAETMDRVNEDRAPLLVTRQKGEPVVMMSLAEYNALEETAYLLRSPANAERLMKSIGELRAGKAKVRQ
LIEE

Download         Length: 255 bp

>AT225016 NZ_CP120837:2443869-2443927 [Salmonella enterica subsp. enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U1R9I4

Antitoxin

Source ID Structure
AlphaFold DB A0A1N7ATY6

References