Detailed information of TA system TA225015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 3438875..3439328
• Replicon: chromosome
• Accession: NZ_CP087177
• Organism: Pseudomonas moraviensis strain B21-039

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOY57_RS14810
• Protein ID: WP_252874547.1
• Coordinates: 3439107..3439328 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2U1RCR7
• Locus tag: LOY57_RS14805
• Protein ID: WP_042606822.1
• Coordinates: 3438875..3439069 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY57_RS14775 (LOY57_14735)	3434107..3434934	+	828	WP_042606825.1	ABC transporter permease	-
LOY57_RS14780 (LOY57_14740)	3434931..3435698	+	768	WP_065616234.1	phosphonate ABC transporter, permease protein PhnE	-
LOY57_RS14785 (LOY57_14745)	3435877..3437556	+	1680	WP_123419425.1	MFS transporter	-
LOY57_RS14790 (LOY57_14750)	3437665..3437883	+	219	WP_042606898.1	hypothetical protein	-
LOY57_RS14795 (LOY57_14755)	3438114..3438308	+	195	WP_083352624.1	stability determinant	-
LOY57_RS14800 (LOY57_14760)	3438271..3438582	+	312	WP_258638290.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LOY57_RS14805 (LOY57_14765)	3438875..3439069	+	195	WP_042606822.1	hypothetical protein	Antitoxin
LOY57_RS14810 (LOY57_14770)	3439107..3439328	+	222	WP_252874547.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (35-67)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8431.81 Da
• Isoelectric Point: 11.1199

>T225015 WP_252874547.1 NZ_CP087177:3439107-3439328 [Pseudomonas moraviensis]
IEYVEQRNTVASLALHQKLSAAARRLSWIPHGFRSGRIPGTREMVINSNYLLVYRVTDQINILTVLHARKKYP

Nucleotide

• Length: 222 bp

>T225015 NZ_CP120837:c989031-988504 [Salmonella enterica subsp. enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7317.21 Da
• Isoelectric Point: 4.5680

>AT225015 WP_042606822.1 NZ_CP087177:3438875-3439069 [Pseudomonas moraviensis]
MSAELSLIVSDFETEEEAASYDRWYRAKVQAALDDPRPPVPHDEAMVLLGQMLEERRKNRRAAG

Nucleotide

• Length: 195 bp

>AT225015 NZ_CP120837:c989318-989028 [Salmonella enterica subsp. enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2U1RCR7