Detailed information of TA system TA022501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 4775900..4776672
• Replicon: chromosome
• Accession: NC_009925
• Organism: Acaryochloris marina MBIC11017

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: B0C1H6
• Locus tag: AM1_RS21485
• Protein ID: WP_012164996.1
• Coordinates: 4776169..4776672 (+)
• Length: 168 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: AM1_RS21480
• Protein ID: WP_148215792.1
• Coordinates: 4775900..4776181 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM1_RS21465	4770902..4771327	-	426	WP_012164991.1	DUF559 domain-containing protein	-
AM1_RS21470	4771843..4773171	+	1329	WP_012164993.1	AAA-like domain-containing protein	-
AM1_RS21475	4773158..4775755	+	2598	WP_049783764.1	AAA-like domain-containing protein	-
AM1_RS21480	4775900..4776181	+	282	WP_148215792.1	DUF1778 domain-containing protein	Antitoxin
AM1_RS21485	4776169..4776672	+	504	WP_012164996.1	GNAT family N-acetyltransferase	Toxin
AM1_RS21490	4776751..4777755	-	1005	WP_012164997.1	sugar ABC transporter substrate-binding protein	-
AM1_RS37695	4778002..4778352	+	351	WP_012164998.1	hypothetical protein	-
AM1_RS21500	4778425..4779108	+	684	WP_012164999.1	hypothetical protein	-
AM1_RS21505	4779105..4780646	+	1542	WP_012165000.1	OmpA family protein	-
AM1_RS21510	4780651..4781091	+	441	WP_012165001.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-92)

Sequences

Toxin

Protein

• Length: 168 a.a.
• Molecular weight: 18331.24 Da
• Isoelectric Point: 10.3785

>T22501 WP_012164996.1 NC_009925:4776169-4776672 [Acaryochloris marina MBIC11017]
VGQLTFTPPTVLSQHHDLSTFKSSSAILNTWLQKKAKHNHGYGYSRVFVVTPKGSDQVAAYYCLSAGSVQRQWLPNRVTR
NAPDPVPAVVLGRLAVDQRYEGLGLGRGLVNHAVAQTLIAANAIGVRVLIVKAKDEKAFAFYRDKCGFLELPDIPLTLID
PLPKRKV

Nucleotide

• Length: 504 bp

>T22501 NC_009925:4776169-4776672 [Acaryochloris marina MBIC11017]
GTGGGACAGCTAACCTTTACCCCTCCCACTGTTCTCAGCCAACATCATGATCTGTCAACCTTTAAAAGCAGTAGTGCCAT
ACTCAATACCTGGCTACAAAAGAAAGCCAAACATAATCATGGCTATGGGTATTCCAGAGTCTTTGTCGTCACACCAAAAG
GGTCAGATCAAGTGGCTGCCTATTACTGTTTGTCTGCGGGTAGTGTGCAACGGCAGTGGCTTCCCAATCGGGTTACCAGG
AATGCCCCTGATCCAGTTCCAGCCGTTGTTCTAGGCCGATTAGCCGTCGATCAGAGGTATGAAGGCTTAGGTTTAGGACG
AGGTTTAGTCAATCATGCTGTTGCTCAAACCCTCATTGCTGCTAATGCAATCGGAGTTAGAGTCTTAATTGTTAAAGCGA
AGGATGAAAAAGCGTTTGCCTTTTACCGAGACAAATGTGGTTTTTTAGAGCTGCCTGATATCCCTCTGACCTTGATTGAT
CCACTACCTAAACGCAAAGTATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10349.57 Da
• Isoelectric Point: 5.6705

>AT22501 WP_148215792.1 NC_009925:4775900-4776181 [Acaryochloris marina MBIC11017]
MSSPTQSTKKKINLKVDPHRGDVIDRAAAVAGKTRTEFMVDASYREAQELLLSQTTFYLSNGGWDAFMEILDNPPEPSAA
RKALQDHQAPWDS

Nucleotide

• Length: 282 bp

>AT22501 NC_009925:4775900-4776181 [Acaryochloris marina MBIC11017]
ATGTCCTCTCCGACACAAAGTACTAAGAAGAAGATTAACCTCAAGGTTGACCCCCATCGTGGAGATGTCATCGACAGAGC
TGCGGCTGTGGCAGGCAAAACAAGAACTGAATTTATGGTGGATGCCTCTTACCGAGAAGCCCAAGAACTATTGCTAAGCC
AAACGACTTTCTATCTATCGAATGGTGGGTGGGATGCCTTTATGGAAATTTTGGACAATCCCCCCGAACCCTCGGCAGCT
CGGAAAGCCCTACAAGATCATCAAGCGCCGTGGGACAGCTAA

Structures

Toxin

• AlphaFold DB: B0C1H6