Detailed information of TA system TA225007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4126239..4126689
• Replicon: chromosome
• Accession: NZ_CP087176
• Organism: Pseudomonas sp. B21-040

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOY55_RS18925
• Protein ID: WP_109786729.1
• Coordinates: 4126239..4126508 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2V2AJ94
• Locus tag: LOY55_RS18930
• Protein ID: WP_046030461.1
• Coordinates: 4126498..4126689 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY55_RS18905 (LOY55_18870)	4122517..4122795	-	279	WP_046030454.1	lipid-A-disaccharide synthase N-terminal domain-containing protein	-
LOY55_RS18910 (LOY55_18875)	4122792..4123532	-	741	WP_109786726.1	glycosyltransferase family 2 protein	-
LOY55_RS18915 (LOY55_18880)	4123576..4124553	-	978	WP_109786727.1	NAD-dependent epimerase	-
LOY55_RS18920 (LOY55_18885)	4124763..4126121	+	1359	WP_258668357.1	M15 family metallopeptidase	-
LOY55_RS18925 (LOY55_18890)	4126239..4126508	-	270	WP_109786729.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY55_RS18930 (LOY55_18895)	4126498..4126689	-	192	WP_046030461.1	hypothetical protein	Antitoxin
LOY55_RS18935 (LOY55_18900)	4127178..4129385	+	2208	WP_258666254.1	hypothetical protein	-
LOY55_RS18940 (LOY55_18905)	4129378..4131396	+	2019	WP_258666257.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10458.08 Da
• Isoelectric Point: 6.4798

>T225007 WP_109786729.1 NZ_CP087176:c4126508-4126239 [Pseudomonas sp. B21-040]
MLVEWRPEARAELWQILDYIGDRHLVAASELYQAIEVATSALPQHPYLYRFGRVPGTREIVVHPIYLVVYRVTDRIEIVT
VLHARQEYP

Nucleotide

• Length: 270 bp

>T225007 NZ_CP120736:c1059374-1059114 [Lacticaseibacillus rhamnosus]
ATGATTAAAACCTGGACCGATGATGCTTGGGCGGACTACATGTATTGGCATGATCAAAACGACAAGCGGACAATCAAACG
AATTAATCAACTCATTCAAGCCATTGACCGTGACCCTTATAAAGGCATCGGAAAACCTGAGCCACTTAGATATGCGCTAA
CCGGAAAATGGTCACGTCGGATTGATCAGGAAAATCGCATCATCTACAGCATTGAAAAGAACCACATTAATATTTTCGCC
TGCCGCACTCACTACAGTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7172.95 Da
• Isoelectric Point: 4.7164

>AT225007 WP_046030461.1 NZ_CP087176:c4126689-4126498 [Pseudomonas sp. B21-040]
MSAELSPIVSEFETEEQAASYDHWFRAKVQASLDDPRPNVPHDQVMADMRALIESKRNKRDAG

Nucleotide

• Length: 192 bp

>AT225007 NZ_CP120736:c1059636-1059367 [Lacticaseibacillus rhamnosus]
ATGGAAGCAACGAATTATAGTGATTTCCGCCGCAACCTTAAGCATTATATGAGTCAAGTCAACGAAGACGCCGAACCGCT
ACTGGTTACCGCTAAAGATGATGATGACAATGTGGTGGTTATGAGCAAGCACGATTTTGACGCCATCGAAGAAACCCTGT
ATTTACTCAGCAATCCCAAGCTGATGGCCAAAATCAAACGTGGTGATGCCCAAATTGCCGCTGGAAAGGCTAAACAGCAC
GAGTTGTTAACGGACTTCGATCATGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A2V2AJ94