Detailed information of TA system TA022500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1284115..1284706
• Replicon: chromosome
• Accession: NC_009925
• Organism: Acaryochloris marina MBIC11017

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0C588
• Locus tag: AM1_RS05770
• Protein ID: WP_012161865.1
• Coordinates: 1284350..1284706 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0C587
• Locus tag: AM1_RS05765
• Protein ID: WP_012161864.1
• Coordinates: 1284115..1284360 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM1_RS05745	1279153..1280337	+	1185	WP_012161859.1	DUF3596 domain-containing protein	-
AM1_RS05750	1280341..1280619	-	279	WP_012161860.1	hypothetical protein	-
AM1_RS40860	1280616..1280828	-	213	WP_148215872.1	hypothetical protein	-
AM1_RS05755	1280821..1283091	-	2271	WP_012161862.1	AAA family ATPase	-
AM1_RS05760	1283252..1283923	+	672	WP_041659240.1	helix-turn-helix transcriptional regulator	-
AM1_RS05765	1284115..1284360	+	246	WP_012161864.1	hypothetical protein	Antitoxin
AM1_RS05770	1284350..1284706	+	357	WP_012161865.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM1_RS05775	1284801..1285067	+	267	WP_041659243.1	hypothetical protein	-
AM1_RS05780	1285046..1285564	+	519	WP_012161867.1	hypothetical protein	-
AM1_RS05785	1285685..1286620	+	936	WP_012161869.1	ATP-binding protein	-
AM1_RS05790	1286617..1287681	+	1065	WP_012161870.1	metal-dependent hydrolase	-
AM1_RS05795	1287668..1288764	+	1097	Protein_1139	ATP-binding protein	-
AM1_RS38530	1288820..1289053	+	234	WP_148215873.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (58-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13728.64 Da
• Isoelectric Point: 9.8730

>T22500 WP_012161865.1 NC_009925:1284350-1284706 [Acaryochloris marina MBIC11017]
MPNNASDIEVALTHRFQRDLRTLAKRYRRIRSDVEPLIEQLQAGELPGDQITGIEYTLFKVRLKNSDIQKGKSAGYRVIY
YLKTQARIILVTIYSKSDRADIDNQTLREAIAQFEQDR

Nucleotide

• Length: 357 bp

>T22500 NC_009925:1284350-1284706 [Acaryochloris marina MBIC11017]
ATGCCGAATAACGCATCAGATATTGAAGTTGCGCTAACCCATCGCTTTCAAAGGGATCTCCGCACCCTCGCTAAGCGCTA
TCGTCGCATTCGCTCCGATGTGGAACCCCTGATTGAGCAACTACAGGCTGGTGAGCTTCCAGGAGATCAGATTACAGGCA
TAGAATACACACTCTTCAAAGTTCGCCTCAAAAATAGTGATATTCAAAAGGGCAAGAGTGCGGGCTATCGGGTTATTTAC
TACCTCAAAACTCAAGCTCGGATCATCTTGGTAACCATCTATTCAAAGTCGGATCGAGCTGACATTGACAACCAAACCTT
GCGAGAAGCGATCGCACAATTTGAGCAAGACCGTTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9001.04 Da
• Isoelectric Point: 3.9129

>AT22500 WP_012161864.1 NC_009925:1284115-1284360 [Acaryochloris marina MBIC11017]
MKAIETTATINDQGQLALDQPLELAQRRRVRVIVLISEEDEPDPDDTPNSVVMDGLRQGFHEALTGQTIPLSQMWDGIDA
E

Nucleotide

• Length: 246 bp

>AT22500 NC_009925:1284115-1284360 [Acaryochloris marina MBIC11017]
ATGAAAGCGATTGAAACTACAGCAACCATTAATGATCAAGGGCAACTCGCCCTTGATCAGCCCCTTGAACTAGCTCAACG
TCGTCGGGTTAGAGTCATTGTCCTTATCTCAGAAGAAGACGAGCCGGATCCTGACGACACTCCAAACTCAGTCGTCATGG
ACGGTCTCCGTCAGGGGTTCCACGAAGCACTCACTGGTCAAACCATCCCTCTCTCGCAAATGTGGGATGGCATTGATGCC
GAATAA

Structures

Toxin

• AlphaFold DB: B0C588

Antitoxin

• AlphaFold DB: B0C587