Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 3607029..3607593 | Replicon | chromosome |
| Accession | NZ_CP087170 | ||
| Organism | Pseudomonas rhodesiae strain B21-046 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A2G0X6W5 |
| Locus tag | LOY39_RS16160 | Protein ID | WP_034099058.1 |
| Coordinates | 3607306..3607593 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A2G0X669 |
| Locus tag | LOY39_RS16155 | Protein ID | WP_034099056.1 |
| Coordinates | 3607029..3607316 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOY39_RS16115 (LOY39_16095) | 3602430..3602747 | - | 318 | WP_258694809.1 | transcriptional regulator | - |
| LOY39_RS16120 (LOY39_16100) | 3602744..3603088 | - | 345 | WP_034099048.1 | toxin | - |
| LOY39_RS16125 (LOY39_16105) | 3603211..3604014 | - | 804 | WP_034099050.1 | phage antirepressor KilAC domain-containing protein | - |
| LOY39_RS16130 (LOY39_16110) | 3604011..3604322 | - | 312 | WP_258694810.1 | DUF3077 domain-containing protein | - |
| LOY39_RS16135 (LOY39_16115) | 3604396..3604551 | - | 156 | WP_258694811.1 | Arc family DNA-binding protein | - |
| LOY39_RS16140 (LOY39_16120) | 3604696..3605082 | + | 387 | WP_258694812.1 | helix-turn-helix transcriptional regulator | - |
| LOY39_RS16145 (LOY39_16125) | 3605332..3606249 | - | 918 | WP_258694813.1 | hypothetical protein | - |
| LOY39_RS16150 (LOY39_16130) | 3606450..3606923 | + | 474 | WP_034099054.1 | hypothetical protein | - |
| LOY39_RS16155 (LOY39_16135) | 3607029..3607316 | + | 288 | WP_034099056.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LOY39_RS16160 (LOY39_16140) | 3607306..3607593 | + | 288 | WP_034099058.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LOY39_RS16165 (LOY39_16145) | 3607633..3608397 | - | 765 | WP_034099060.1 | KilA-N domain-containing protein | - |
| LOY39_RS16170 (LOY39_16150) | 3608510..3608728 | - | 219 | WP_034099062.1 | hypothetical protein | - |
| LOY39_RS16175 (LOY39_16155) | 3608751..3609059 | - | 309 | WP_034114377.1 | hypothetical protein | - |
| LOY39_RS16180 (LOY39_16160) | 3609137..3609347 | - | 211 | Protein_3187 | hypothetical protein | - |
| LOY39_RS16185 (LOY39_16165) | 3610174..3610407 | + | 234 | WP_258694814.1 | Arc family DNA-binding protein | - |
| LOY39_RS16190 (LOY39_16170) | 3610559..3610906 | + | 348 | WP_258694815.1 | hypothetical protein | - |
| LOY39_RS16195 (LOY39_16175) | 3610995..3611315 | + | 321 | WP_232925112.1 | hypothetical protein | - |
| LOY39_RS16200 (LOY39_16180) | 3611201..3612382 | + | 1182 | WP_258695808.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3595243..3612752 | 17509 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11017.87 Da Isoelectric Point: 10.2255
>T224985 WP_034099058.1 NZ_CP087170:3607306-3607593 [Pseudomonas rhodesiae]
MAAEYEVEWDPKALKELRKLDGTIRLQFLKKLQERQSGPRVPGDALHGMKDCYKIKLRGAGYRLVYRVEDERIVILVLAV
GKRERSSVYEQAGKR
MAAEYEVEWDPKALKELRKLDGTIRLQFLKKLQERQSGPRVPGDALHGMKDCYKIKLRGAGYRLVYRVEDERIVILVLAV
GKRERSSVYEQAGKR
Download Length: 288 bp
>T224985 NZ_CP120681:2042965-2043144 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10290.83 Da Isoelectric Point: 4.4354
>AT224985 WP_034099056.1 NZ_CP087170:3607029-3607316 [Pseudomonas rhodesiae]
MQNILADVAVSVSELKKNPSSVLSGANGMPVAVLNHNRVMGYMVPANVYEAMVERLDELELVQLVKARLDAKETPVRVSL
DDLIGETEADIANGR
MQNILADVAVSVSELKKNPSSVLSGANGMPVAVLNHNRVMGYMVPANVYEAMVERLDELELVQLVKARLDAKETPVRVSL
DDLIGETEADIANGR
Download Length: 288 bp
>AT224985 NZ_CP120681:c2043290-2043068 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2G0X6W5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2G0X669 |