Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2292659..2293269 Replicon chromosome
Accession NZ_CP087170
Organism Pseudomonas rhodesiae strain B21-046

Toxin (Protein)


Gene name hicA Uniprot ID A0A2G0WYT7
Locus tag LOY39_RS10475 Protein ID WP_034096965.1
Coordinates 2293018..2293269 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY39_RS10470 Protein ID WP_034096964.1
Coordinates 2292659..2293021 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY39_RS10450 (LOY39_10445) 2287879..2288907 - 1029 WP_034096960.1 ABC transporter ATP-binding protein -
LOY39_RS10455 (LOY39_10450) 2289151..2289981 + 831 WP_258695644.1 IclR family transcriptional regulator -
LOY39_RS10460 (LOY39_10455) 2290085..2291440 + 1356 WP_034096962.1 MATE family efflux transporter -
LOY39_RS10465 (LOY39_10460) 2291482..2292654 + 1173 WP_034096963.1 MFS transporter -
LOY39_RS10470 (LOY39_10465) 2292659..2293021 - 363 WP_034096964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY39_RS10475 (LOY39_10470) 2293018..2293269 - 252 WP_034096965.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9497.05 Da        Isoelectric Point: 10.0458

>T224983 WP_034096965.1 NZ_CP087170:c2293269-2293018 [Pseudomonas rhodesiae]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDSGDPTAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T224983 NZ_CP120681:c1584690-1584514 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13134.99 Da        Isoelectric Point: 7.0377

>AT224983 WP_034096964.1 NZ_CP087170:c2293021-2292659 [Pseudomonas rhodesiae]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALISYEGKTVADLDAAFQAAVDDYLVTCQNLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALSEFLQHHFAELHPSA

Download         Length: 363 bp

>AT224983 NZ_CP120681:1584631-1584731 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCATTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G0WYT7

Antitoxin

Source ID Structure

References