Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 4352609..4353197 Replicon chromosome
Accession NZ_CP087169
Organism Pseudomonas sp. B21-047

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LOY26_RS19775 Protein ID WP_095063759.1
Coordinates 4352609..4352911 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LOY26_RS19780 Protein ID WP_095063760.1
Coordinates 4352904..4353197 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY26_RS19750 4348609..4348737 - 129 WP_256214945.1 PA1414 family protein -
LOY26_RS19755 (LOY26_19730) 4348863..4349756 - 894 WP_033699637.1 LysR family transcriptional regulator -
LOY26_RS19760 (LOY26_19735) 4349862..4351043 + 1182 WP_258714022.1 MFS transporter -
LOY26_RS19765 (LOY26_19740) 4351053..4351979 - 927 WP_258714023.1 DMT family transporter -
LOY26_RS19770 (LOY26_19745) 4352086..4352481 - 396 WP_033699644.1 transcriptional regulator -
LOY26_RS19775 (LOY26_19750) 4352609..4352911 + 303 WP_095063759.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY26_RS19780 (LOY26_19755) 4352904..4353197 + 294 WP_095063760.1 putative addiction module antidote protein Antitoxin
LOY26_RS19785 (LOY26_19760) 4353310..4353582 + 273 WP_033699650.1 hypothetical protein -
LOY26_RS19790 (LOY26_19765) 4353637..4354998 - 1362 WP_033699652.1 DEAD/DEAH box helicase -
LOY26_RS19795 (LOY26_19770) 4355103..4356404 + 1302 WP_186658075.1 mechanosensitive ion channel family protein -
LOY26_RS19800 (LOY26_19775) 4356449..4356652 - 204 WP_258714024.1 hypothetical protein -
LOY26_RS19805 (LOY26_19780) 4356663..4357538 - 876 WP_033699658.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11485.17 Da        Isoelectric Point: 10.6088

>T224981 WP_095063759.1 NZ_CP087169:4352609-4352911 [Pseudomonas sp. B21-047]
MKKIESSSFRHWVHGLRDDTARIRIIARINRLMEGLPGDVSAVGHGVSELRIHYGPGYRVYFHQSGDTLVILLCGGHKSS
QRRDIKAAHEILRSWRMQHD

Download         Length: 303 bp

>T224981 NZ_CP120681:c1584495-1584244 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATCAAAGATTACTTCAGCAGCGAAGGACAGGCGCTAA
TCAACACAATTTTTGTTGTCACATGTATCATTGCCATATTGTTATGGATCATCTATTGTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10517.96 Da        Isoelectric Point: 5.5740

>AT224981 WP_095063760.1 NZ_CP087169:4352904-4353197 [Pseudomonas sp. B21-047]
MTETFFDFDAADYLTTPQAIAQFMSDALETGDASYVAKAVGVVARAKGMSELAKETGLSREQLYRSFSEHGNPTLKSFLA
VMKALGIDMTAKPHLAH

Download         Length: 294 bp

>AT224981 NZ_CP120681:1584473-1584573 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References