Detailed information of TA system TA022498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 854305..854875
• Replicon: chromosome
• Accession: NC_009925
• Organism: Acaryochloris marina MBIC11017

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0BYN7
• Locus tag: AM1_RS03910
• Protein ID: WP_012161495.1
• Coordinates: 854579..854875 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0BYN6
• Locus tag: AM1_RS03905
• Protein ID: WP_012161494.1
• Coordinates: 854305..854598 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM1_RS03870	849573..850145	-	573	Protein_755	Uma2 family endonuclease	-
AM1_RS03880	850175..851331	+	1157	WP_148215638.1	IS3-like element ISAcma13 family transposase	-
AM1_RS03885	851474..851932	-	459	WP_012161490.1	urease accessory protein UreE	-
AM1_RS03890	852264..853013	+	750	WP_202947664.1	phosphoadenosine phosphosulfate reductase	-
AM1_RS03895	853068..853349	+	282	WP_012161492.1	hypothetical protein	-
AM1_RS03900	853418..854203	+	786	WP_012161493.1	class I SAM-dependent methyltransferase	-
AM1_RS03905	854305..854598	+	294	WP_012161494.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AM1_RS03910	854579..854875	+	297	WP_012161495.1	Txe/YoeB family addiction module toxin	Toxin
AM1_RS03915	854888..855532	-	645	WP_012161496.1	DUF4033 domain-containing protein	-
AM1_RS03920	855646..856182	-	537	WP_012161497.1	pentapeptide repeat-containing protein	-
AM1_RS03925	856421..857086	-	666	WP_012161499.1	class I SAM-dependent methyltransferase	-
AM1_RS03930	857270..858106	+	837	WP_012161500.1	DUF2059 domain-containing protein	-
AM1_RS03935	858106..858621	+	516	WP_063710512.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (21-98)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-76)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11592.60 Da
• Isoelectric Point: 10.3683

>T22498 WP_012161495.1 NC_009925:854579-854875 [Acaryochloris marina MBIC11017]
MGKKKAKFIPTEVKWEIILDQNFREDLQYWIQQDRKLALRLLAVVESIAINPFTGIGKPEALKHLGSNLWSRRLNQEHRI
VYLVRDGKVYLLAAKYHY

Nucleotide

• Length: 297 bp

>T22498 NC_009925:854579-854875 [Acaryochloris marina MBIC11017]
TTGGGGAAGAAGAAGGCTAAGTTTATCCCTACTGAGGTCAAGTGGGAAATCATCCTTGATCAAAATTTTAGAGAAGATTT
GCAGTATTGGATTCAACAGGATCGGAAGCTGGCACTAAGGTTACTGGCTGTGGTTGAATCCATTGCCATAAATCCATTTA
CTGGCATTGGCAAGCCCGAAGCTCTTAAGCATCTAGGTTCTAATTTGTGGTCCCGACGCCTGAATCAAGAACACCGCATT
GTGTATCTTGTTCGGGATGGGAAAGTATATCTGCTAGCAGCAAAATATCACTATTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10557.78 Da
• Isoelectric Point: 4.1712

>AT22498 WP_012161494.1 NC_009925:854305-854598 [Acaryochloris marina MBIC11017]
MLPKTLSYSQARANFAETLNDVEDNRSIVIVQRPNRPGVALIAADELSSMMETVHLLRSPANATRLFDAIARAEAGEGQP
TTLDELTQELGFGEEEG

Nucleotide

• Length: 294 bp

>AT22498 NC_009925:854305-854598 [Acaryochloris marina MBIC11017]
ATGCTGCCAAAAACCCTTAGTTATAGTCAGGCTCGTGCTAATTTTGCAGAGACCCTGAATGATGTTGAAGACAATCGCTC
TATTGTCATTGTTCAACGTCCTAATCGACCCGGTGTGGCTTTAATTGCGGCAGATGAGCTGAGCAGCATGATGGAAACGG
TTCACCTACTGAGATCGCCCGCCAATGCCACCCGTCTCTTTGATGCGATCGCACGAGCTGAAGCGGGAGAAGGACAGCCC
ACTACTCTAGATGAACTCACCCAGGAGCTGGGCTTTGGGGAAGAAGAAGGCTAA

Structures

Toxin

• AlphaFold DB: B0BYN7

Antitoxin

• AlphaFold DB: B0BYN6