Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1564426..1565042 Replicon chromosome
Accession NZ_CP087168
Organism Pseudomonas sp. B21-048

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY56_RS07170 Protein ID WP_258620743.1
Coordinates 1564426..1564638 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY56_RS07175 Protein ID WP_258620744.1
Coordinates 1564638..1565042 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY56_RS07145 (LOY56_07130) 1559533..1561536 + 2004 WP_258620738.1 heme lyase CcmF/NrfE family subunit -
LOY56_RS07150 (LOY56_07135) 1561533..1562069 + 537 WP_258620739.1 DsbE family thiol:disulfide interchange protein -
LOY56_RS07155 (LOY56_07140) 1562066..1562539 + 474 WP_258620740.1 cytochrome c-type biogenesis protein CcmH -
LOY56_RS07160 (LOY56_07145) 1562532..1563734 + 1203 WP_258620741.1 c-type cytochrome biogenesis protein CcmI -
LOY56_RS07165 (LOY56_07150) 1563749..1564153 + 405 WP_258620742.1 hypothetical protein -
LOY56_RS07170 (LOY56_07155) 1564426..1564638 + 213 WP_258620743.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY56_RS07175 (LOY56_07160) 1564638..1565042 + 405 WP_258620744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY56_RS07180 (LOY56_07165) 1565166..1566371 - 1206 WP_258620745.1 MFS transporter -
LOY56_RS07185 (LOY56_07170) 1566510..1567701 - 1192 Protein_1406 osmoprotectant NAGGN system M42 family peptidase -
LOY56_RS07190 (LOY56_07175) 1567842..1569587 - 1746 WP_258620746.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7830.10 Da        Isoelectric Point: 10.3517

>T224974 WP_258620743.1 NZ_CP087168:1564426-1564638 [Pseudomonas sp. B21-048]
VQSRLLIKELIEAGWTLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPIGTIKSIRRRAGLYCPGASLAGDP

Download         Length: 213 bp

>T224974 NZ_CP120671:c4165689-4165405 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14891.91 Da        Isoelectric Point: 4.3313

>AT224974 WP_258620744.1 NZ_CP087168:1564638-1565042 [Pseudomonas sp. B21-048]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAVEIAHIMLQEIMADGESIPMPTSAAAHRENPEFADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLIRH

Download         Length: 405 bp

>AT224974 NZ_CP120671:c4165927-4165679 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References