Detailed information of TA system TA224969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2173470..2173920
• Replicon: chromosome
• Accession: NZ_CP087167
• Organism: Pseudomonas atacamensis strain B21-050

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOY49_RS09585
• Protein ID: WP_130899483.1
• Coordinates: 2173470..2173739 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A341FF08
• Locus tag: LOY49_RS09590
• Protein ID: WP_038862015.1
• Coordinates: 2173729..2173920 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY49_RS09565 (LOY49_09540)	2169057..2169680	+	624	WP_016774080.1	isochorismate family cysteine hydrolase YcaC	-
LOY49_RS09570 (LOY49_09545)	2169724..2171151	-	1428	WP_073474277.1	mechanosensitive ion channel family protein	-
LOY49_RS09575 (LOY49_09550)	2171260..2172282	-	1023	WP_073474278.1	alpha/beta hydrolase	-
LOY49_RS09580 (LOY49_09555)	2172498..2173397	+	900	WP_024012435.1	LysR family transcriptional regulator	-
LOY49_RS09585 (LOY49_09560)	2173470..2173739	-	270	WP_130899483.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY49_RS09590 (LOY49_09565)	2173729..2173920	-	192	WP_038862015.1	hypothetical protein	Antitoxin
LOY49_RS09595 (LOY49_09570)	2174229..2175026	+	798	WP_130899482.1	class I SAM-dependent methyltransferase	-
LOY49_RS09600 (LOY49_09575)	2175154..2175462	-	309	WP_071171759.1	putative addiction module antidote protein	-
LOY49_RS09605 (LOY49_09580)	2175779..2176471	-	693	WP_122700563.1	N-acetyltransferase	-
LOY49_RS09610 (LOY49_09585)	2176529..2177320	-	792	WP_122700564.1	ChbG/HpnK family deacetylase	-
LOY49_RS09615 (LOY49_09590)	2177292..2178479	-	1188	WP_130899480.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10321.70 Da
• Isoelectric Point: 6.8793

>T224969 WP_130899483.1 NZ_CP087167:c2173739-2173470 [Pseudomonas atacamensis]
MQIEWRPEAKADLSNILRYIGERNFAAAVSLSKSIEESTTSLSVHPHLYRKDRSPGTREIVVHPNYVVIYEVTDRIEILS
VLHTRQEYP

Nucleotide

• Length: 270 bp

>T224969 NZ_CP120671:1630092-1630403 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7132.82 Da
• Isoelectric Point: 4.5698

>AT224969 WP_038862015.1 NZ_CP087167:c2173920-2173729 [Pseudomonas atacamensis]
MDGKIFPDDSGFENDEQAASHDRWLRAKVQASRDDPHPSLPHEDVMADMHALIESMRKKADAD

Nucleotide

• Length: 192 bp

>AT224969 NZ_CP120671:1630404-1630694 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A341FF08