Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1713815..1714854 Replicon chromosome
Accession NZ_CP087167
Organism Pseudomonas atacamensis strain B21-050

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag LOY49_RS07570 Protein ID WP_258605563.1
Coordinates 1713815..1714390 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag LOY49_RS07575 Protein ID WP_258605565.1
Coordinates 1714387..1714854 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY49_RS07545 (LOY49_07525) 1709155..1711143 + 1989 WP_258605559.1 heme lyase CcmF/NrfE family subunit -
LOY49_RS07550 (LOY49_07530) 1711140..1711676 + 537 WP_024012128.1 DsbE family thiol:disulfide interchange protein -
LOY49_RS07555 (LOY49_07535) 1711673..1712143 + 471 WP_110601105.1 cytochrome c-type biogenesis protein CcmH -
LOY49_RS07560 (LOY49_07540) 1712140..1713339 + 1200 WP_258605561.1 c-type cytochrome biogenesis protein CcmI -
LOY49_RS07565 (LOY49_07545) 1713365..1713769 + 405 WP_016771039.1 hypothetical protein -
LOY49_RS07570 (LOY49_07550) 1713815..1714390 - 576 WP_258605563.1 PIN domain-containing protein Toxin
LOY49_RS07575 (LOY49_07555) 1714387..1714854 - 468 WP_258605565.1 helix-turn-helix domain-containing protein Antitoxin
LOY49_RS07580 (LOY49_07560) 1715038..1715250 + 213 WP_076566640.1 type II toxin-antitoxin system HicA family toxin -
LOY49_RS07585 (LOY49_07565) 1715250..1715654 + 405 WP_130901292.1 type II toxin-antitoxin system HicB family antitoxin -
LOY49_RS07590 (LOY49_07570) 1715835..1717022 - 1188 WP_024012134.1 MFS transporter -
LOY49_RS07595 (LOY49_07575) 1717189..1718187 - 999 WP_110601117.1 sulfate ABC transporter substrate-binding protein -
LOY49_RS07600 (LOY49_07580) 1718292..1719116 - 825 WP_016771032.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21674.69 Da        Isoelectric Point: 6.1390

>T224967 WP_258605563.1 NZ_CP087167:c1714390-1713815 [Pseudomonas atacamensis]
VRHSSFTAVYDACVLYPAPLRDFLMWLALSGLYRARWTQEIHHEWKRNLLKNRSDLTLEQLDRTSQLMDLAIPDACIDGY
EDLVSGLTLPDENDRHVLAAAIRCGADVIVTFNLKDFPSRHLAPYGIEAQHPDEFVENLFHLDSAAVVAAAQSQRRQLKT
PNVEVDKYLGFLQRQGLVESVKALGNYRAIL

Download         Length: 576 bp

>T224967 NZ_CP120671:c1232574-1232089 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17179.59 Da        Isoelectric Point: 6.6497

>AT224967 WP_258605565.1 NZ_CP087167:c1714854-1714387 [Pseudomonas atacamensis]
MTTATPSAINLPVEREVKAAIEGQRALAAFLASGFETQRIQIFDEQNEAHSVELPTSALRLLSDILAALAQGNAVKVVPI
HAELTTQEAADLLNVSRPHMIKLLERGEISYHKTGKHRRVRFADLMEYKTRRDTASEQAMTLLAEQAQALRTGYE

Download         Length: 468 bp

>AT224967 NZ_CP120671:c1232849-1232562 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References