Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 878113..878702 Replicon chromosome
Accession NZ_CP087167
Organism Pseudomonas atacamensis strain B21-050

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY49_RS03715 Protein ID WP_217879323.1
Coordinates 878451..878702 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY49_RS03710 Protein ID WP_056782875.1
Coordinates 878113..878454 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY49_RS03685 (LOY49_03675) 873816..874217 + 402 WP_016771753.1 30S ribosome-binding factor RbfA -
LOY49_RS03690 (LOY49_03680) 874222..875139 + 918 WP_024011571.1 tRNA pseudouridine(55) synthase TruB -
LOY49_RS03695 (LOY49_03685) 875283..875552 + 270 WP_016771751.1 30S ribosomal protein S15 -
LOY49_RS03700 (LOY49_03690) 875757..877862 + 2106 WP_024011572.1 polyribonucleotide nucleotidyltransferase -
LOY49_RS03710 (LOY49_03700) 878113..878454 - 342 WP_056782875.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY49_RS03715 (LOY49_03705) 878451..878702 - 252 WP_217879323.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY49_RS03720 (LOY49_03710) 879058..879357 + 300 WP_258604893.1 DUF6388 family protein -
LOY49_RS03725 (LOY49_03715) 879445..880293 - 849 WP_016771747.1 carboxylating nicotinate-nucleotide diphosphorylase -
LOY49_RS03730 (LOY49_03720) 880561..882738 + 2178 WP_258604895.1 DUF1631 domain-containing protein -
LOY49_RS03735 (LOY49_03725) 882803..883363 + 561 WP_122699435.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9183.59 Da        Isoelectric Point: 10.3167

>T224966 WP_217879323.1 NZ_CP087167:c878702-878451 [Pseudomonas atacamensis]
MSKTEKLLAKLINGHSAFTWSELVTLLGRLGYSQLEGSGSRIKFDNGDPNALINLHKPHPGNEIKTYARRQIIEQLKTGG
LIP

Download         Length: 252 bp

>T224966 NZ_CP120671:c1122338-1121970 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTTGCTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12593.23 Da        Isoelectric Point: 6.3189

>AT224966 WP_056782875.1 NZ_CP087167:c878454-878113 [Pseudomonas atacamensis]
MSSQLHYKGYVGSIEASTEDKCLFGKLLFIRALVNYEGQTVAELEAAFREAVDDYLQTCQQLGQKPEIPCKGSFNVRIGH
DLHLAAALAATRQNVSLNDLTRQALNEYLQHHA

Download         Length: 342 bp

>AT224966 NZ_CP120671:c1122556-1122335 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References