Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3995056..3996095 Replicon chromosome
Accession NZ_CP087165
Organism Pseudomonas sichuanensis strain B21-052

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag LOY46_RS18745 Protein ID WP_258704795.1
Coordinates 3995520..3996095 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag LOY46_RS18740 Protein ID WP_258704794.1
Coordinates 3995056..3995523 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY46_RS18720 (LOY46_18700) 3990674..3991693 + 1020 WP_125464851.1 ABC transporter permease -
LOY46_RS18725 (LOY46_18705) 3991695..3993305 + 1611 WP_258704791.1 ABC transporter ATP-binding protein -
LOY46_RS18730 (LOY46_18710) 3994060..3994308 + 249 WP_258704792.1 hypothetical protein -
LOY46_RS18735 (LOY46_18715) 3994463..3994732 + 270 WP_258704793.1 DUF3077 domain-containing protein -
LOY46_RS18740 (LOY46_18720) 3995056..3995523 + 468 WP_258704794.1 helix-turn-helix domain-containing protein Antitoxin
LOY46_RS18745 (LOY46_18725) 3995520..3996095 + 576 WP_258704795.1 PIN domain-containing protein Toxin
LOY46_RS18750 (LOY46_18730) 3996309..3997361 + 1053 WP_258704796.1 DUF2235 domain-containing protein -
LOY46_RS18755 (LOY46_18735) 3997380..3997745 - 366 WP_258704797.1 hypothetical protein -
LOY46_RS18760 (LOY46_18740) 3997742..3998710 - 969 WP_258704798.1 LysR family transcriptional regulator -
LOY46_RS18765 (LOY46_18745) 3998996..4000231 + 1236 WP_258704799.1 diaminopimelate decarboxylase -
LOY46_RS18770 (LOY46_18750) 4000361..4001059 - 699 WP_153786626.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21601.75 Da        Isoelectric Point: 4.7714

>T224953 WP_258704795.1 NZ_CP087165:3995520-3996095 [Pseudomonas sichuanensis]
MKHSSFTALYDANVLYPAPLRDLLMNLALTGVYRARWLARIHDEWKRNLLINRPDLDRTQLDRTSGLMDEAVPDALVSDY
EPLMGGLDLPDEDDRHVLAAAIKCNASVIVTFNLKDFPDTALGSFDIEALHPDDFIADLRDLDKAAVLEAAQRQRQSLKN
PALSVQAYLDKLLQQKLPESVKLLSEFRFLL

Download         Length: 576 bp

>T224953 NZ_CP120638:3646151-3646420 [Rhizobium sp. 32-5/1]
TTGGTCTGGACGATTGACATAACCAACAATGCTGAAAAGGCATTGCGGAAGATGGGCTCTTCCGATGTGCGTCGCCTCCG
CGACTTTCTTTTTGGCCGGGTTGCGCTTCTCGACGATCCTCGCCAGATCGGCCAAGCCTTGCAGGGCAATGAACTCGGTC
ATCTCTGGCGTTACCGTGTCGGGGACTTTCGCGTTCTCTGTGAAATCCGCGATAACCGCCTTGTTATTCTTGTGGTCGAA
ATCGGTCATCGTCGCGAAGTCTACAGATGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17203.67 Da        Isoelectric Point: 6.3371

>AT224953 WP_258704794.1 NZ_CP087165:3995056-3995523 [Pseudomonas sichuanensis]
MTTTDLSRNMLPDDNEIAVAVESSRTLAAFLSTAAHTQRIELLNDANQRQVVEVPTFALRLFGEILSELALGNAVKVVPI
HAELTTQEAADLLNVSRPHLVKLLDEGLMPHTKTGRHRRVKFADLVAYKNKRDAISRTAMDELAAQAQDLRMGYE

Download         Length: 468 bp

>AT224953 NZ_CP120638:3645934-3646167 [Rhizobium sp. 32-5/1]
ATGACACGACAGACTGCGATACGTCTCCCCGATGAGACATATGAACGGCTACAAGTGCTGGCGACGCGGACCGGCAGGAC
CGCGACCTATTATATCCGGGAAGCGATCGAACAGCATCTTGAAGACCTCGAGGATATCTATCTGGCGGAGCAGGTTCTGG
AGAAGCTGGCCCGCGGTGAAATCACCACACGCCCTCTAGCGGAAGTGATGGCCGAGCTTGGTCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References