224950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 293751..294373 Replicon chromosome
Accession NZ_CP087165
Organism Pseudomonas sichuanensis strain B21-052

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY46_RS01420 Protein ID WP_258705527.1
Coordinates 293751..293942 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY46_RS01425 Protein ID WP_125462239.1
Coordinates 293960..294373 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY46_RS01410 (LOY46_01410) 290462..291781 + 1320 WP_125462237.1 OprD family porin -
LOY46_RS01415 (LOY46_01415) 291812..293482 - 1671 WP_258705526.1 FMN-binding glutamate synthase family protein -
LOY46_RS01420 (LOY46_01420) 293751..293942 + 192 WP_258705527.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY46_RS01425 (LOY46_01425) 293960..294373 + 414 WP_125462239.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY46_RS01430 (LOY46_01430) 294401..295120 - 720 WP_258705528.1 response regulator transcription factor -
LOY46_RS01435 (LOY46_01435) 295273..296415 - 1143 WP_258705529.1 copper-containing nitrite reductase -
LOY46_RS01440 (LOY46_01440) 296591..296806 + 216 WP_125857131.1 hypothetical protein -
LOY46_RS01450 (LOY46_01450) 297052..297300 - 249 WP_258705530.1 hypothetical protein -
LOY46_RS01455 (LOY46_01455) 297956..298315 + 360 WP_258705531.1 SMR family transporter -
LOY46_RS01460 (LOY46_01460) 298309..298626 + 318 WP_125462245.1 multidrug/spermidine efflux SMR transporter subunit MdtI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7048.17 Da        Isoelectric Point: 10.7339

>T224950 WP_258705527.1 NZ_CP087165:293751-293942 [Pseudomonas sichuanensis]
MNSREMISVIEADGWYLVRSKGSHHHFKHPQKTGLVTIPHPKKDLLPATAASILRQARIGYAS

Download         Length: 192 bp

>T224950 NZ_CP120638:c625479-625201 [Rhizobium sp. 32-5/1]
ATGATCAGATCGATCGCCAATCGCGCCACCCGGCAGTTTCTGGAAAACGGAAAAACAAAATTTTCCGGCATGGATGTCGA
TAAAGCAAAAATGCGGGCGATGATGCTGCACAATGCTCGGTCCCTTGATGACTTGGTGCCATTGAAGTCCGTTGGTATTC
ATAAGCTGTCCGGAGATCGGAAGATGCAATGGGCCATGACGATCAACGGCCCTTGGCGGTTATGTTTCAGATTCGAGGAT
GGGCATGCGTATGATGTGGAGATCGTGGACGATCATTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14897.99 Da        Isoelectric Point: 4.5047

>AT224950 WP_125462239.1 NZ_CP087165:293960-294373 [Pseudomonas sichuanensis]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDDAIAMAREAIEGHLELLAQDGQEIPKASKVSVHAANPDYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDAYVKNHPEQKSRSGFLAEAALRILQGDCK

Download         Length: 414 bp

>AT224950 NZ_CP120638:c625204-624902 [Rhizobium sp. 32-5/1]
TTGAAGGAGCACACGATGTTTGAAATTCACCCCGGAACGATGCTGAAGGAAGAACTCGAAGCGCGTGGCATGAGCGGAAA
TGCGCTGGCATTGGCGTTGCGGATAAATTCAGGCCGGGTCTCCGAAATCTTGAACGGCAAACGTGCAGTGTCTGCGGACA
CGGCACTTCGGCTTGGCCGGTTTTTCGGGAATGACCCTCAGTTCTGGCTAGGGCTTCAGGCAAGCTATGATCTTGCTGTT
GCTTCGCGCCAAAATGGTGAACGCATCAATCTGGAAGTGCTGCCCGCTCAATCTGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References