Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3836087..3836970 Replicon chromosome
Accession NZ_CP087160
Organism Pseudomonas sp. CIP-10

Toxin (Protein)


Gene name - Uniprot ID A0A2K4LSC9
Locus tag LMH93_RS17355 Protein ID WP_012052908.1
Coordinates 3836087..3836524 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID I7C3Q7
Locus tag LMH93_RS17360 Protein ID WP_003250525.1
Coordinates 3836521..3836970 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH93_RS17340 (LMH93_17340) 3832388..3833617 - 1230 WP_230064416.1 acyl-CoA dehydrogenase -
LMH93_RS17345 (LMH93_17345) 3833758..3834681 + 924 WP_004573723.1 LysR family transcriptional regulator -
LMH93_RS17350 (LMH93_17350) 3834875..3836029 + 1155 WP_098091291.1 aminotransferase class V-fold PLP-dependent enzyme -
LMH93_RS17355 (LMH93_17355) 3836087..3836524 - 438 WP_012052908.1 RES family NAD+ phosphorylase Toxin
LMH93_RS17360 (LMH93_17360) 3836521..3836970 - 450 WP_003250525.1 DUF2384 domain-containing protein Antitoxin
LMH93_RS17365 (LMH93_17365) 3837113..3837766 - 654 WP_004573726.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
LMH93_RS17370 (LMH93_17370) 3837870..3838793 + 924 WP_004573727.1 LysR family transcriptional regulator -
LMH93_RS17375 (LMH93_17375) 3838842..3839672 + 831 WP_003250518.1 AraC family transcriptional regulator -
LMH93_RS17380 (LMH93_17380) 3839724..3840308 + 585 WP_003250516.1 LysE family transporter -
LMH93_RS17385 (LMH93_17385) 3840348..3841547 - 1200 WP_014861778.1 sugar transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15944.21 Da        Isoelectric Point: 5.6016

>T224945 WP_012052908.1 NZ_CP087160:c3836524-3836087 [Pseudomonas sp. CIP-10]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDGSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 438 bp

>T224945 NZ_CP120633:5064302-5064679 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGTCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16956.46 Da        Isoelectric Point: 5.7258

>AT224945 WP_003250525.1 NZ_CP087160:c3836970-3836521 [Pseudomonas sp. CIP-10]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp

>AT224945 NZ_CP120633:5063890-5064255 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGGGGGCTACCCTGCACCGTGACGCCCTGTTT
CGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGTTCAGCGATG
CGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAAT
CCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTGTGGTTACGT
TTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4LSC9

Antitoxin

Source ID Structure
AlphaFold DB I7C3Q7

References