Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2966781..2968020 Replicon chromosome
Accession NZ_CP087156
Organism Roseibium aggregatum strain LZB033

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ST40_RS13625 Protein ID WP_075283634.1
Coordinates 2966781..2967401 (-) Length 207 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ST40_RS13630 Protein ID WP_075283633.1
Coordinates 2967451..2968020 (-) Length 190 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ST40_RS13605 (ST40_013605) 2963334..2963795 - 462 WP_023000201.1 Lrp/AsnC family transcriptional regulator -
ST40_RS13610 (ST40_013610) 2963900..2965366 + 1467 WP_075283635.1 aminotransferase class V-fold PLP-dependent enzyme -
ST40_RS13615 (ST40_013615) 2965383..2966171 + 789 WP_023000199.1 class II glutamine amidotransferase -
ST40_RS13620 (ST40_013620) 2966270..2966641 - 372 WP_023000198.1 STAS/SEC14 domain-containing protein -
ST40_RS13625 (ST40_013625) 2966781..2967401 - 621 WP_075283634.1 HD domain-containing protein Toxin
ST40_RS13630 (ST40_013630) 2967451..2968020 - 570 WP_075283633.1 helix-turn-helix transcriptional regulator Antitoxin
ST40_RS13635 (ST40_013635) 2968109..2968735 - 627 WP_075283632.1 DapH/DapD/GlmU-related protein -
ST40_RS13640 (ST40_013640) 2969135..2969968 + 834 WP_075283654.1 phosphonate ABC transporter ATP-binding protein -
ST40_RS13645 (ST40_013645) 2970027..2970941 + 915 WP_023000193.1 phosphonate ABC transporter substrate-binding protein -
ST40_RS13650 (ST40_013650) 2971124..2971972 + 849 WP_075283631.1 phosphonate ABC transporter, permease protein PhnE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(28-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-68)


Sequences

Toxin        


Download         Length: 207 a.a.        Molecular weight: 23120.28 Da        Isoelectric Point: 4.6200

>T224941 WP_075283634.1 NZ_CP087156:c2967401-2966781 [Roseibium aggregatum]
MTKTPPSLDLSEISHTRLTGLLDFLQAAEQLKDTLRSGTTTGGRPESTAEHSWRLALMVLLFEPELKEIDMLKLLKLTLV
HDLGEAISGDVPAPLQTPGDDRQERERRDFLTLCEPLPGDVAGELTSLWDEYAAARTVEARLAKAFDKLETMLQHVLMPR
QAPSFYEFNLGYGRDRTDCSALTRQLRDEVDELTRTMMTGAGREFA

Download         Length: 621 bp

>T224941 NZ_CP120633:4150911-4151195 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 190 a.a.        Molecular weight: 21618.54 Da        Isoelectric Point: 7.3881

>AT224941 WP_075283633.1 NZ_CP087156:c2968020-2967451 [Roseibium aggregatum]
MQTETAVLESSLGPSLRRWRVLNRVKQEALAHELGVSQTRISRWESGKSQPDDSDRAKITRLLRARPESAADKALLDLVS
RSAVPVHLVCDLTHRLLAISVPRACEWRAPVNEFLNRPLWRFASEGIRATEHRLTDYGWFEPDAPDIVYRTEHVDFPEMT
IPESTIRISRLPLSDGRFARLVREEQDAA

Download         Length: 570 bp

>AT224941 NZ_CP120633:4150675-4150908 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References