Detailed information of TA system TA022494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1331221..1331739
• Replicon: chromosome
• Accession: NC_009900
• Organism: Rickettsia massiliae MTU5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: RMA_RS09035
• Protein ID: WP_012153252.1
• Coordinates: 1331221..1331376 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: H8LNX5
• Locus tag: RMA_RS07255
• Protein ID: WP_012151450.1
• Coordinates: 1331476..1331739 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RMA_RS07220	1327357..1327644	+	288	WP_187145892.1	restriction endonuclease subunit S	-
RMA_RS07225	1327757..1327975	+	219	WP_041404909.1	hypothetical protein	-
RMA_RS07230	1327965..1328222	+	258	WP_041405062.1	restriction endonuclease subunit S	-
RMA_RS07235	1328226..1329371	+	1146	WP_014366180.1	succinyl-diaminopimelate desuccinylase	-
RMA_RS07245	1329530..1329994	+	465	WP_014408049.1	DNA polymerase III subunit chi	-
RMA_RS07250	1330000..1331082	-	1083	WP_041405063.1	LptF/LptG family permease	-
RMA_RS09035	1331221..1331376	-	156	WP_012153252.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
RMA_RS07255	1331476..1331739	-	264	WP_012151450.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
RMA_RS07260	1331832..1332479	-	648	WP_014408052.1	phosphatase PAP2 family protein	-
RMA_RS07265	1332494..1333258	+	765	WP_014408053.1	MBL fold metallo-hydrolase	-
RMA_RS07270	1333262..1333984	+	723	WP_012153256.1	amino acid ABC transporter ATP-binding protein	-
RMA_RS07700	1334201..1334479	+	279	Protein_1470	type II toxin-antitoxin system Phd/YefM family antitoxin	-
RMA_RS07280	1334701..1335120	+	420	WP_041404910.1	serine hydrolase	-
RMA_RS07285	1335278..1335490	+	213	Protein_1472	serine hydrolase	-
RMA_RS07290	1335550..1336245	+	696	WP_014366188.1	TIGR02281 family clan AA aspartic protease	-
RMA_RS09045	1336297..1336413	-	117	WP_081427949.1	palindromic element RPE1 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (12-49)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6002.90 Da
• Isoelectric Point: 7.1018

>T22494 WP_012153252.1 NC_009900:c1331376-1331221 [Rickettsia massiliae MTU5]
MTYTYERPCPYSNWKDCRDCHIKPDLVLIYRKPDADTLELIRLGSHSALGF

Nucleotide

• Length: 156 bp

>T22494 NC_009900:c1331376-1331221 [Rickettsia massiliae MTU5]
ATGACCTATACATATGAGAGACCATGCCCTTATAGTAATTGGAAAGATTGTAGAGATTGTCATATTAAACCGGATTTAGT
ATTAATTTATAGAAAACCCGATGCTGACACATTGGAGTTAATACGATTAGGTTCACACAGTGCACTTGGTTTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9516.03 Da
• Isoelectric Point: 5.0916

>AT22494 WP_012151450.1 NC_009900:c1331739-1331476 [Rickettsia massiliae MTU5]
MSADSIVRARINEDVKEEAALVLAAMGLTLSDAVRMLLFRVAREKALPFEPLIPNDETIKAMKAARSGKLVHVGNINNLL
SDLNEND

Nucleotide

• Length: 264 bp

>AT22494 NC_009900:c1331739-1331476 [Rickettsia massiliae MTU5]
ATGTCTGCTGATTCTATTGTGCGAGCCCGTATTAATGAAGACGTGAAAGAAGAAGCAGCTTTAGTGCTTGCTGCTATGGG
ACTTACTTTATCTGATGCTGTTCGTATGCTGTTATTTCGTGTTGCTCGTGAAAAAGCATTGCCGTTTGAGCCACTTATCC
CAAATGATGAAACAATTAAAGCTATGAAAGCTGCAAGAAGCGGCAAATTAGTTCATGTTGGTAATATCAATAATTTGTTA
TCTGATTTAAATGAGAACGATTAA

Structures

Antitoxin

• AlphaFold DB: H8LNX5