Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4913917..4914433 Replicon chromosome
Accession NZ_CP087151
Organism Klebsiella pneumoniae strain KP14

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LOX93_RS24350 Protein ID WP_002886902.1
Coordinates 4913917..4914201 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LOX93_RS24355 Protein ID WP_002886901.1
Coordinates 4914191..4914433 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX93_RS24325 (LOX93_24325) 4909401..4909664 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LOX93_RS24330 (LOX93_24330) 4909794..4909967 + 174 WP_002886906.1 hypothetical protein -
LOX93_RS24335 (LOX93_24335) 4909970..4910713 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LOX93_RS24340 (LOX93_24340) 4911070..4913208 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LOX93_RS24345 (LOX93_24345) 4913449..4913913 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LOX93_RS24350 (LOX93_24350) 4913917..4914201 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOX93_RS24355 (LOX93_24355) 4914191..4914433 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOX93_RS24360 (LOX93_24360) 4914511..4916421 - 1911 WP_004152270.1 PRD domain-containing protein -
LOX93_RS24365 (LOX93_24365) 4916444..4917598 - 1155 WP_002886900.1 lactonase family protein -
LOX93_RS24370 (LOX93_24370) 4917664..4918404 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T224930 WP_002886902.1 NZ_CP087151:c4914201-4913917 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T224930 NZ_CP120633:c2240037-2239630 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT224930 WP_002886901.1 NZ_CP087151:c4914433-4914191 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT224930 NZ_CP120633:c2240284-2240018 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References