Detailed information of TA system TA022492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1236834..1237332
• Replicon: chromosome
• Accession: NC_009882
• Organism: Rickettsia rickettsii str. Sheila Smith

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0H3AWA1
• Locus tag: A1G_RS06555
• Protein ID: WP_012151451.1
• Coordinates: 1237189..1237332 (+)
• Length: 48 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: H8LNX5
• Locus tag: A1G_RS06550
• Protein ID: WP_012151450.1
• Coordinates: 1236834..1237097 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1G_RS08020	1232084..1232200	+	117	WP_080508248.1	palindromic element RPE1 domain-containing protein	-
A1G_RS06510	1232252..1232947	-	696	WP_012151442.1	TIGR02281 family clan AA aspartic protease	-
A1G_RS06515	1233008..1233226	-	219	WP_012151443.1	serine hydrolase	-
A1G_RS08850	1233787..1233906	-	120	WP_196218302.1	serine hydrolase	-
A1G_RS06530	1234144..1234383	-	240	WP_012151447.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
A1G_RS06535	1234588..1235310	-	723	WP_010977895.1	amino acid ABC transporter ATP-binding protein	-
A1G_RS06540	1235314..1236078	-	765	WP_012151448.1	MBL fold metallo-hydrolase	-
A1G_RS06545	1236093..1236740	+	648	WP_012151449.1	phosphatase PAP2 family protein	-
A1G_RS06550	1236834..1237097	+	264	WP_012151450.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
A1G_RS06555	1237189..1237332	+	144	WP_012151451.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
A1G_RS06560	1237468..1238550	+	1083	WP_014362438.1	LptF/LptG family permease	-
A1G_RS06565	1238556..1239020	-	465	WP_012151453.1	DNA polymerase III subunit chi	-
A1G_RS06575	1239220..1240365	-	1146	WP_012151455.1	succinyl-diaminopimelate desuccinylase	-
A1G_RS06580	1240369..1240623	-	255	WP_012151456.1	restriction endonuclease subunit S	-
A1G_RS08485	1240927..1241127	-	201	WP_155105224.1	restriction endonuclease subunit S	-
A1G_RS06585	1241123..1241314	-	192	WP_014362439.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-45)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5357.17 Da
• Isoelectric Point: 6.4361

>T22492 WP_012151451.1 NC_009882:1237189-1237332 [Rickettsia rickettsii str. 'Sheila Smith']
MRDHALIGNWKDCRDCHIKADLVLIYRKPDADTLELIQLGSNSTLGF

Nucleotide

• Length: 144 bp

>T22492 NC_009882:1237189-1237332 [Rickettsia rickettsii str. 'Sheila Smith']
ATGAGAGATCATGCCCTTATAGGTAATTGGAAAGATTGTAGAGATTGTCATATTAAAGCGGATTTAGTATTAATTTATAG
AAAACCCGATGCTGACACATTGGAGTTAATACAATTAGGTTCAAACAGTACACTTGGTTTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9516.03 Da
• Isoelectric Point: 5.0916

>AT22492 WP_012151450.1 NC_009882:1236834-1237097 [Rickettsia rickettsii str. 'Sheila Smith']
MSADSIVRARINEDVKEEAALVLAAMGLTLSDAVRMLLFRVAREKALPFEPLIPNDETIKAMKAARSGKLVHVGNINNLL
SDLNEND

Nucleotide

• Length: 264 bp

>AT22492 NC_009882:1236834-1237097 [Rickettsia rickettsii str. 'Sheila Smith']
ATGTCTGCTGATTCTATTGTGCGAGCCCGTATTAATGAAGACGTGAAAGAAGAAGCAGCTTTAGTGCTTGCTGCTATGGG
ACTTACTTTATCTGATGCTGTTCGTATGCTGTTATTTCGTGTTGCTCGTGAAAAAGCATTGCCGTTTGAACCACTTATCC
CAAATGATGAAACAATTAAAGCTATGAAAGCTGCAAGAAGCGGCAAATTAGTTCATGTTGGTAATATCAATAATTTGTTA
TCTGATTTAAATGAGAACGATTAA

Structures

Toxin

• AlphaFold DB: A0A0H3AWA1

Antitoxin

• AlphaFold DB: H8LNX5