Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916885..4917401 Replicon chromosome
Accession NZ_CP087142
Organism Klebsiella pneumoniae strain KP15

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LOX91_RS24370 Protein ID WP_002886902.1
Coordinates 4916885..4917169 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LOX91_RS24375 Protein ID WP_002886901.1
Coordinates 4917159..4917401 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX91_RS24345 (LOX91_24345) 4912369..4912632 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LOX91_RS24350 (LOX91_24350) 4912762..4912935 + 174 WP_002886906.1 hypothetical protein -
LOX91_RS24355 (LOX91_24355) 4912938..4913681 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LOX91_RS24360 (LOX91_24360) 4914038..4916176 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LOX91_RS24365 (LOX91_24365) 4916417..4916881 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LOX91_RS24370 (LOX91_24370) 4916885..4917169 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOX91_RS24375 (LOX91_24375) 4917159..4917401 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOX91_RS24380 (LOX91_24380) 4917479..4919389 - 1911 WP_004152270.1 PRD domain-containing protein -
LOX91_RS24385 (LOX91_24385) 4919412..4920566 - 1155 WP_002886900.1 lactonase family protein -
LOX91_RS24390 (LOX91_24390) 4920632..4921372 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T224877 WP_002886902.1 NZ_CP087142:c4917169-4916885 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T224877 NZ_CP120568:2387294-2387581 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT224877 WP_002886901.1 NZ_CP087142:c4917401-4917159 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT224877 NZ_CP120568:2387055-2387294 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References