224865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875688..876342 Replicon chromosome
Accession NZ_CP087142
Organism Klebsiella pneumoniae strain KP15

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LOX91_RS04420 Protein ID WP_004144731.1
Coordinates 875935..876342 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LOX91_RS04415 Protein ID WP_002916312.1
Coordinates 875688..875954 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX91_RS04390 (LOX91_04390) 870844..872277 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LOX91_RS04395 (LOX91_04395) 872396..873124 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LOX91_RS04400 (LOX91_04400) 873174..873485 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LOX91_RS04405 (LOX91_04405) 873649..874308 + 660 WP_002916317.1 hemolysin III family protein -
LOX91_RS04410 (LOX91_04410) 874459..875442 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LOX91_RS04415 (LOX91_04415) 875688..875954 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LOX91_RS04420 (LOX91_04420) 875935..876342 + 408 WP_004144731.1 protein YgfX Toxin
LOX91_RS04425 (LOX91_04425) 876349..876870 - 522 WP_002916308.1 flavodoxin FldB -
LOX91_RS04430 (LOX91_04430) 876971..877867 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LOX91_RS04435 (LOX91_04435) 877890..878603 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LOX91_RS04440 (LOX91_04440) 878609..880342 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T224865 WP_004144731.1 NZ_CP087142:875935-876342 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T224865 NZ_CP120567:c4186848-4186450 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT224865 WP_002916312.1 NZ_CP087142:875688-875954 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT224865 NZ_CP120567:c4187144-4186851 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References