Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3589834..3590417 Replicon chromosome
Accession NZ_CP087138
Organism Pseudomonas sp. KNUC1026

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LN139_RS16850 Protein ID WP_236355297.1
Coordinates 3589834..3590199 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LN139_RS16855 Protein ID WP_236355298.1
Coordinates 3590193..3590417 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN139_RS16840 (LN139_16840) 3585636..3588670 - 3035 Protein_3347 FAD-binding and (Fe-S)-binding domain-containing protein -
LN139_RS16845 (LN139_16845) 3588825..3589697 + 873 WP_236355296.1 LysR substrate-binding domain-containing protein -
LN139_RS16850 (LN139_16850) 3589834..3590199 - 366 WP_236355297.1 type II toxin-antitoxin system VapC family toxin Toxin
LN139_RS16855 (LN139_16855) 3590193..3590417 - 225 WP_236355298.1 ribbon-helix-helix protein, CopG family Antitoxin
LN139_RS16860 (LN139_16860) 3590503..3591660 - 1158 WP_236360471.1 MFS transporter -
LN139_RS16865 (LN139_16865) 3591821..3593878 - 2058 WP_236355299.1 HAMP domain-containing methyl-accepting chemotaxis protein -
LN139_RS16875 (LN139_16875) 3594287..3594961 + 675 WP_236355300.1 two-component system response regulator CreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-104)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13428.80 Da        Isoelectric Point: 7.0122

>T224861 WP_236355297.1 NZ_CP087138:c3590199-3589834 [Pseudomonas sp. KNUC1026]
MVKLLYGANILIDYLNGIVPAQLELDKAANPMISVITWMEVMAGTSAAEEGDIRAWLETFQLIRLDSKIADVAVSIRKLR
RIKLPDAIVWASAKAHSAVLVSRNVKDFPPQEADVRVPYLL

Download         Length: 366 bp

>T224861 NZ_CP120567:3069116-3069223 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8485.61 Da        Isoelectric Point: 5.8150

>AT224861 WP_236355298.1 NZ_CP087138:c3590417-3590193 [Pseudomonas sp. KNUC1026]
MARILVDLPDDQLESLATIGAREMRPRAALIRDAVAQYLSSHRSAEQTSAKVFGLWRDRAVDGVKYQQELREEW

Download         Length: 225 bp

>AT224861 NZ_CP120567:c3069063-3069002 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References