Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 92346..92905 Replicon plasmid pAPEC-O1-ColBM
Accession NC_009837
Organism Escherichia coli APEC O1

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2XJR9
Locus tag APECO1_RS26210 Protein ID WP_000421266.1
Coordinates 92630..92905 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H2XL20
Locus tag APECO1_RS26205 Protein ID WP_012006537.1
Coordinates 92346..92630 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APECO1_RS26185 88104..88865 - 762 WP_000020503.1 ABC transporter ATP-binding protein -
APECO1_RS26190 88865..89902 - 1038 WP_000110580.1 iron ABC transporter permease -
APECO1_RS26195 89902..90900 - 999 WP_000756335.1 ABC transporter substrate-binding protein -
APECO1_RS28010 91050..91208 - 159 Protein_97 integrase core domain-containing protein -
APECO1_RS26200 91255..91845 - 591 WP_000086535.1 recombinase family protein -
APECO1_RS26205 92346..92630 + 285 WP_012006537.1 ribbon-helix-helix domain-containing protein Antitoxin
APECO1_RS26210 92630..92905 + 276 WP_000421266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APECO1_RS26215 93011..93250 + 240 WP_001105068.1 hypothetical protein -
APECO1_RS26230 94942..97080 + 2139 WP_000350635.1 AAA family ATPase -
APECO1_RS26235 97242..97658 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin -
APECO1_RS26240 97655..97885 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / iroN / iroE / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA 1..174241 174241
- inside IScluster/Tn - - 78096..94240 16144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10779.47 Da        Isoelectric Point: 9.9324

>T22486 WP_000421266.1 NC_009837:92630-92905 [Escherichia coli APEC O1]
MELKWTSKALSDLARLYDFLVLASKPAATRTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T22486 NC_009837:92630-92905 [Escherichia coli APEC O1]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCACCAGAACGGTGCAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10501.96 Da        Isoelectric Point: 6.4632

>AT22486 WP_012006537.1 NC_009837:92346-92630 [Escherichia coli APEC O1]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVKSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT22486 NC_009837:92346-92630 [Escherichia coli APEC O1]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCAATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGAAATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XJR9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2XL20

References