Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4341571..4342068 Replicon chromosome
Accession NZ_CP087136
Organism Escherichia coli strain JW5503

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LOX89_RS21065 Protein ID WP_001173343.1
Coordinates 4341895..4342068 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LOX89_RS21060 Protein ID WP_000398619.1
Coordinates 4341571..4341867 (+) Length 99 a.a.

Genomic Context

LOX89_RS21050LOX89_RS21055LOX89_RS21060LOX89_RS21065LOX89_RS21040LOX89_RS21045LOX89_RS21070LOX89_RS21075
Location: 4340830..4341060 (231 bp)
Type: Others
Protein ID: WP_000371704.1
Location: 4341072..4341344 (273 bp)
Type: Others
Protein ID: WP_000405651.1
Location: 4341571..4341867 (297 bp)
Type: Antitoxin
Protein ID: WP_000398619.1
Location: 4341895..4342068 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Location: 4338302..4339021 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Location: 4339018..4340649 (1632 bp)
Type: Others
Protein ID: WP_001216477.1
Location: 4342187..4343704 (1518 bp)
Type: Others
Protein ID: WP_001295074.1
Location: 4343941..4345398 (1458 bp)
Type: Others
Protein ID: WP_000856829.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LOX89_RS21040 (4338302)4338302..4339021-720WP_000611288.1two-component system response regulator DcuR-
LOX89_RS21045 (4339018)4339018..4340649-1632WP_001216477.1sensor histidine kinase-
LOX89_RS21050 (4340830)4340830..4341060+231WP_000371704.14Fe-4S mono-cluster protein YjdI-
LOX89_RS21055 (4341072)4341072..4341344+273WP_000405651.1GNAT family N-acetyltransferase-
LOX89_RS21060 (4341571)4341571..4341867+297WP_000398619.1type V toxin-antitoxin system endoribonuclease antitoxin GhoSAntitoxin
LOX89_RS21065 (4341895)4341895..4342068+174WP_001173343.1type V toxin-antitoxin system toxin GhoTToxin
LOX89_RS21070 (4342187)4342187..4343704-1518WP_001295074.1lysine--tRNA ligase-
LOX89_RS21075 (4343941)4343941..4345398-1458WP_000856829.1dipeptide/tripeptide permease DtpC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T224851 WP_001173343.1 NZ_CP087136:4341895-4342068 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T224851 NZ_CP120567:c865819-865355 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT224851 WP_000398619.1 NZ_CP087136:4341571-4341867 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT224851 NZ_CP120567:c866154-865819 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9QI41

Antitoxin

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Source
ID
Structure
PDB2LLZ
AlphaFold DBA0A7U9QBH6

References