Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 2868707..2869294 Replicon chromosome
Accession NZ_CP087132
Organism Flavobacterium sp. F-29

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LNP19_RS12460 Protein ID WP_230062239.1
Coordinates 2868707..2868886 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LNP19_RS12465 Protein ID WP_230062240.1
Coordinates 2869010..2869294 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNP19_RS12445 (LNP19_12445) 2864041..2865807 + 1767 WP_230062236.1 RagB/SusD family nutrient uptake outer membrane protein -
LNP19_RS12450 (LNP19_12450) 2866959..2867378 - 420 WP_230062237.1 PepSY-like domain-containing protein -
LNP19_RS12455 (LNP19_12455) 2867842..2868459 + 618 WP_230062238.1 hypothetical protein -
LNP19_RS12460 (LNP19_12460) 2868707..2868886 + 180 WP_230062239.1 hypothetical protein Toxin
LNP19_RS12465 (LNP19_12465) 2869010..2869294 + 285 WP_230062240.1 putative addiction module antidote protein Antitoxin
LNP19_RS12470 (LNP19_12470) 2869863..2870537 + 675 WP_230062241.1 hypothetical protein -
LNP19_RS12475 (LNP19_12475) 2870664..2871848 + 1185 WP_230062242.1 PQQ-binding-like beta-propeller repeat protein -
LNP19_RS12480 (LNP19_12480) 2872024..2872953 + 930 WP_230062243.1 hypothetical protein -
LNP19_RS12485 (LNP19_12485) 2873156..2873509 + 354 WP_230062244.1 DUF4377 domain-containing protein -
LNP19_RS12490 (LNP19_12490) 2873685..2874104 + 420 WP_230062245.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-59)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7100.23 Da        Isoelectric Point: 8.9740

>T224813 WP_230062239.1 NZ_CP087132:2868707-2868886 [Flavobacterium sp. F-29]
MYFIEKTTEFDKWFKKLNDFRAKAKILFRLQKLEKDEHFGDCEPVGDGIRELKINYAKG

Download         Length: 180 bp

>T224813 NZ_CP120557:c2577531-2577235 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10288.80 Da        Isoelectric Point: 4.7906

>AT224813 WP_230062240.1 NZ_CP087132:2869010-2869294 [Flavobacterium sp. F-29]
METSKFDIADYLDSNEMIAEYLNTVLEEGNDAEIVTAIGHIAKAIGMTKIAEETRMSRPSLYKALSEGSKPQFSTIMKVL
KAIGGQIHINPLTS

Download         Length: 285 bp

>AT224813 NZ_CP120557:c2577233-2576838 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References