Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4641432..4641948 Replicon chromosome
Accession NZ_CP087122
Organism Klebsiella pneumoniae strain TH12852

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LOX64_RS22520 Protein ID WP_002886902.1
Coordinates 4641432..4641716 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LOX64_RS22525 Protein ID WP_002886901.1
Coordinates 4641706..4641948 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX64_RS22495 (4636848) 4636848..4637111 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LOX64_RS22500 (4637241) 4637241..4637414 + 174 WP_032410138.1 hypothetical protein -
LOX64_RS22505 (4637417) 4637417..4638160 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LOX64_RS22510 (4638517) 4638517..4640655 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LOX64_RS22515 (4640964) 4640964..4641428 + 465 WP_229982366.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LOX64_RS22520 (4641432) 4641432..4641716 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOX64_RS22525 (4641706) 4641706..4641948 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOX64_RS22530 (4642026) 4642026..4643936 - 1911 WP_023280782.1 PRD domain-containing protein -
LOX64_RS22535 (4643959) 4643959..4645113 - 1155 WP_009309312.1 lactonase family protein -
LOX64_RS22540 (4645180) 4645180..4645920 - 741 WP_229982367.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T224779 WP_002886902.1 NZ_CP087122:c4641716-4641432 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T224779 NZ_CP120549:1152647-1152982 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT224779 WP_002886901.1 NZ_CP087122:c4641948-4641706 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT224779 NZ_CP120549:1152399-1152647 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References