Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2192422..2192969 Replicon chromosome
Accession NZ_CP087114
Organism Bartonella machadoae strain 46A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LNM86_RS10355 Protein ID WP_241437611.1
Coordinates 2192422..2192748 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LNM86_RS10360 Protein ID WP_241437612.1
Coordinates 2192745..2192969 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNM86_RS10325 (LNM86_10325) 2188423..2189358 + 936 WP_241438992.1 YopJ/AvrA family T3SS effector serine/threonine acetyltransferase -
LNM86_RS10330 (LNM86_10330) 2189946..2190794 + 849 WP_241438993.1 YopJ/AvrA family T3SS effector serine/threonine acetyltransferase -
LNM86_RS10335 (LNM86_10335) 2191046..2191378 - 333 WP_241437609.1 hypothetical protein -
LNM86_RS10340 (LNM86_10340) 2191371..2191574 + 204 Protein_2025 late control protein -
LNM86_RS10345 (LNM86_10345) 2191643..2191954 - 312 WP_241437610.1 addiction module antidote protein -
LNM86_RS10350 (LNM86_10350) 2191967..2192288 - 322 Protein_2027 type II toxin-antitoxin system RelE/ParE family toxin -
LNM86_RS10355 (LNM86_10355) 2192422..2192748 - 327 WP_241437611.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LNM86_RS10360 (LNM86_10360) 2192745..2192969 - 225 WP_241437612.1 antitoxin MazE family protein Antitoxin
LNM86_RS10365 (LNM86_10365) 2193154..2193816 + 663 WP_241437613.1 lysozyme -
LNM86_RS10370 (LNM86_10370) 2193940..2194116 + 177 Protein_2031 lysozyme -
LNM86_RS10375 (LNM86_10375) 2194212..2194415 + 204 Protein_2032 lysozyme -
LNM86_RS10380 (LNM86_10380) 2194512..2194721 + 210 Protein_2033 lysozyme -
LNM86_RS10385 (LNM86_10385) 2194818..2195040 + 223 Protein_2034 lysozyme -
LNM86_RS10390 (LNM86_10390) 2195037..2195264 + 228 WP_241437614.1 hypothetical protein -
LNM86_RS10395 (LNM86_10395) 2195197..2195415 + 219 WP_241437615.1 hypothetical protein -
LNM86_RS10400 (LNM86_10400) 2195396..2195614 + 219 WP_241437616.1 hypothetical protein -
LNM86_RS10405 (LNM86_10405) 2195858..2196760 + 903 WP_241437617.1 porin family protein -
LNM86_RS10410 (LNM86_10410) 2196850..2197626 + 777 WP_241437618.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(7-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11751.13 Da        Isoelectric Point: 9.3700

>T224765 WP_241437611.1 NZ_CP087114:c2192748-2192422 [Bartonella machadoae]
MMRGSLVTIAMQGDFGKPRPALIIQANQFSEHTSVTVLPITSTLIAAPLLRITIQPDAKNGLQKLSQVMIDKIMTVGCEK
VILAFGSMHADKMVEIERCLAVFLGIVK

Download         Length: 327 bp

>T224765 NZ_CP120511:c1382676-1381930 [Bacillus sp. B28]
ATGCTTTTATTCTTTCAAATCATGGTCTGGTGCACTATGGCCGCTTTAGGCTTATACGTATACGCCACATGGCGGTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGAAAAACATGGTATTTGCTGTTTGTTTTGGGCGCCATGATATACTGGA
CATATGATCCCTCTTCCCTGTTCACAAACTGGGAACGGTATGTCATTGTCGCTGTCAGCTTTGCTTTAATTGACGCTTTT
ATCTTTTTGAGCGCTTATGTGAAAAAACTGGCCGGCAGTGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCGATCGGCTGAAAACATACCAATATCTATTGAAAAACGAACCGATTCATGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGAATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAATCTGACGGCCAGCCTT
TGTCACTATTCGACACAGTCTGATAAAGACCGGTTAACCGAGCACATGGAGGATCCCGCTGACGTGCAAACGAGGCTGGA
TCGAAAGGATGTCTATTACGACCAGTATGGAAAAGTAGTGCTCATTCCCTTTACAATCGAGACACAGAGCTATGTCATCA
AACTGACGTCTGACAGTATTGTAACGGAATTTGATTATTTGCTATTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8764.06 Da        Isoelectric Point: 8.5634

>AT224765 WP_241437612.1 NZ_CP087114:c2192969-2192745 [Bartonella machadoae]
MATMHVNERVQKHRNAQRKAGLRLMQIWVPDTRQPNFAEECRRQCRLVAKMDKTDTSMQLFMDQSVVDVDGWTE

Download         Length: 225 bp

>AT224765 NZ_CP120511:c1381930-1381760 [Bacillus sp. B28]
ATGGAAAACGCGTTTCAAAACGGATGCCATCCGCGGGCAAAGAAACCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCACACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGATGAGTATAAACGTA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References