Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1344566..1345158 | Replicon | chromosome |
| Accession | NZ_CP087114 | ||
| Organism | Bartonella machadoae strain 46A | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LNM86_RS06555 | Protein ID | WP_241438850.1 |
| Coordinates | 1344958..1345158 (-) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LNM86_RS06550 | Protein ID | WP_241438849.1 |
| Coordinates | 1344566..1344961 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNM86_RS06515 (LNM86_06515) | 1340485..1341045 | - | 561 | WP_241438841.1 | hypothetical protein | - |
| LNM86_RS06520 (LNM86_06520) | 1341098..1341412 | + | 315 | WP_241438842.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LNM86_RS06525 (LNM86_06525) | 1341429..1341725 | + | 297 | WP_004861504.1 | HigA family addiction module antitoxin | - |
| LNM86_RS06530 (LNM86_06530) | 1341770..1342048 | - | 279 | WP_241438844.1 | hypothetical protein | - |
| LNM86_RS06535 (LNM86_06535) | 1342045..1342779 | - | 735 | WP_241438846.1 | antA/AntB antirepressor family protein | - |
| LNM86_RS06540 (LNM86_06540) | 1343340..1343921 | - | 582 | WP_241438848.1 | hypothetical protein | - |
| LNM86_RS06545 (LNM86_06545) | 1343925..1344245 | - | 321 | WP_241438941.1 | hypothetical protein | - |
| LNM86_RS06550 (LNM86_06550) | 1344566..1344961 | - | 396 | WP_241438849.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LNM86_RS06555 (LNM86_06555) | 1344958..1345158 | - | 201 | WP_241438850.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LNM86_RS06560 (LNM86_06560) | 1345228..1345764 | - | 537 | WP_241438851.1 | hypothetical protein | - |
| LNM86_RS06565 (LNM86_06565) | 1345774..1346226 | - | 453 | WP_241438852.1 | single-stranded DNA-binding protein | - |
| LNM86_RS06570 (LNM86_06570) | 1346419..1346718 | + | 300 | WP_241438853.1 | BrnT family toxin | - |
| LNM86_RS06575 (LNM86_06575) | 1346696..1347001 | + | 306 | WP_241438854.1 | BrnA antitoxin family protein | - |
| LNM86_RS06580 (LNM86_06580) | 1347087..1347581 | - | 495 | WP_241438856.1 | hypothetical protein | - |
| LNM86_RS06585 (LNM86_06585) | 1348004..1348195 | + | 192 | WP_015399257.1 | hypothetical protein | - |
| LNM86_RS06590 (LNM86_06590) | 1348266..1348694 | + | 429 | WP_241438858.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LNM86_RS06595 (LNM86_06595) | 1348745..1349278 | - | 534 | WP_241438860.1 | antA/AntB antirepressor family protein | - |
| LNM86_RS06600 (LNM86_06600) | 1349513..1349851 | - | 339 | WP_241438862.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1209361..1408772 | 199411 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7511.81 Da Isoelectric Point: 10.7890
>T224763 WP_241438850.1 NZ_CP087114:c1345158-1344958 [Bartonella machadoae]
MEQDSRKIIAKLKRDGFELVKVRGSHHKLKKDDKVVIVPHPKKNLPIGTARSIAQQAGWLKKGEEE
MEQDSRKIIAKLKRDGFELVKVRGSHHKLKKDDKVVIVPHPKKNLPIGTARSIAQQAGWLKKGEEE
Download Length: 201 bp
>T224763 NZ_CP120508:c2603669-2603409 [Paraburkholderia sp. SUR17]
ATGCGCACCATCCCATTCACCGACGCCCGCGCCAATTTGAAGCGCGTCATTGACCAGGTTGTTGATGATGTGGACGTAAC
GCTCATTACCCGCCGCGACGCACCCAATGCGGTTGTCATGTCCCAGGAACATTACGATAGCTTGATGGAAACGGTCCATC
TGCTGCGCTCCCCGGCAAACGTAGCTCATCTGGAGCGCTCTATCGCGCAGTCACGCGCGGGCAAGGTCAAGCCCCGCAAG
TTGGTCGACGACAGCGAATGA
ATGCGCACCATCCCATTCACCGACGCCCGCGCCAATTTGAAGCGCGTCATTGACCAGGTTGTTGATGATGTGGACGTAAC
GCTCATTACCCGCCGCGACGCACCCAATGCGGTTGTCATGTCCCAGGAACATTACGATAGCTTGATGGAAACGGTCCATC
TGCTGCGCTCCCCGGCAAACGTAGCTCATCTGGAGCGCTCTATCGCGCAGTCACGCGCGGGCAAGGTCAAGCCCCGCAAG
TTGGTCGACGACAGCGAATGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14724.75 Da Isoelectric Point: 4.2870
>AT224763 WP_241438849.1 NZ_CP087114:c1344961-1344566 [Bartonella machadoae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEKNLITNATEALQLYCEDMDTVPMPLKFEEVIQQQSVKTALAEGAFLI
QVPFIENDAEVVRMNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEKNLITNATEALQLYCEDMDTVPMPLKFEEVIQQQSVKTALAEGAFLI
QVPFIENDAEVVRMNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT224763 NZ_CP120508:c2603412-2603146 [Paraburkholderia sp. SUR17]
ATGAGCGGCGCTTTGAACATCATGTGGACTGCCGAGGCCTGGGACGATTACGTCTACTGGCAGGGGCAGGACAAAAGGAC
GTTGAAGCGCATCAATCAACTCATCAAGGATATGCAGCGCTCCCCATTCGAAGGCATCGGCAAACCCGAGTCGCTGAAGG
AAAACCTGACGGGTTTTTGGTCGCGCCGCATTGATGAAACGAATCGCTTGGTCTACGAAGTCGCGAGTACGCAAATCAAT
ATCGTTTCGTGCCGGTACCACTACTGA
ATGAGCGGCGCTTTGAACATCATGTGGACTGCCGAGGCCTGGGACGATTACGTCTACTGGCAGGGGCAGGACAAAAGGAC
GTTGAAGCGCATCAATCAACTCATCAAGGATATGCAGCGCTCCCCATTCGAAGGCATCGGCAAACCCGAGTCGCTGAAGG
AAAACCTGACGGGTTTTTGGTCGCGCCGCATTGATGAAACGAATCGCTTGGTCTACGAAGTCGCGAGTACGCAAATCAAT
ATCGTTTCGTGCCGGTACCACTACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|