Detailed information of TA system TA224760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1159528..1160059
• Replicon: chromosome
• Accession: NZ_CP087114
• Organism: Bartonella machadoae strain 46A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LNM86_RS05485
• Protein ID: WP_241438928.1
• Coordinates: 1159778..1160059 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: LNM86_RS05480
• Protein ID: WP_241438752.1
• Coordinates: 1159528..1159791 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNM86_RS05460 (LNM86_05460)	1155121..1156662	-	1542	WP_241438185.1	phage portal protein	-
LNM86_RS05465 (LNM86_05465)	1156662..1156910	-	249	WP_241438023.1	hypothetical protein	-
LNM86_RS05470 (LNM86_05470)	1156914..1158842	-	1929	WP_241438186.1	phage terminase large subunit family protein	-
LNM86_RS05475 (LNM86_05475)	1158835..1159395	-	561	WP_241438751.1	hypothetical protein	-
LNM86_RS05480 (LNM86_05480)	1159528..1159791	+	264	WP_241438752.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LNM86_RS05485 (LNM86_05485)	1159778..1160059	+	282	WP_241438928.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LNM86_RS05490 (LNM86_05490)	1160111..1160389	-	279	WP_241438753.1	hypothetical protein	-
LNM86_RS05495 (LNM86_05495)	1160386..1161117	-	732	WP_241438754.1	antA/AntB antirepressor family protein	-
LNM86_RS05500 (LNM86_05500)	1161681..1161959	-	279	WP_241438755.1	hypothetical protein	-
LNM86_RS05505 (LNM86_05505)	1161956..1162699	-	744	WP_241438756.1	antA/AntB antirepressor family protein	-
LNM86_RS05510 (LNM86_05510)	1163022..1163564	-	543	WP_241438929.1	hypothetical protein	-
LNM86_RS05515 (LNM86_05515)	1163607..1163927	-	321	WP_241438930.1	hypothetical protein	-
LNM86_RS05520 (LNM86_05520)	1164277..1164459	+	183	WP_241438030.1	type II toxin-antitoxin system HicA family toxin	-
LNM86_RS05525 (LNM86_05525)	1164480..1164902	+	423	WP_241438031.1	type II toxin-antitoxin system HicB family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1089827..1184271	94444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11210.96 Da
• Isoelectric Point: 10.4159

>T224760 WP_241438928.1 NZ_CP087114:1159778-1160059 [Bartonella machadoae]
MRTIERTTIFKRDFKREMRGRYRHLLETDLRQIIAALANDQPLEPRHHDHALTGNWKDYRDCHIRPDLVLIYRLIGQDRL
ILVRLGSHSQLNL

Nucleotide

• Length: 282 bp

>T224760 NZ_CP120426:c1370846-1370658 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9647.87 Da
• Isoelectric Point: 4.0201

>AT224760 WP_241438752.1 NZ_CP087114:1159528-1159791 [Bartonella machadoae]
MATSRMVQARVPEEIQNVANQVIQASGLSVSDVVRVLMTRIAQDKAIPSFLFQPNAETIAAFTELDEGNLKKFNSVDELF
DDLYADD

Nucleotide

• Length: 264 bp

>AT224760 NZ_CP120426:c1371128-1370871 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA