Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 798257..798830 Replicon chromosome
Accession NZ_CP087114
Organism Bartonella machadoae strain 46A

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LNM86_RS03715 Protein ID WP_241438487.1
Coordinates 798519..798830 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LNM86_RS03710 Protein ID WP_241438486.1
Coordinates 798257..798538 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNM86_RS03680 (LNM86_03680) 793440..793646 - 207 WP_241437493.1 DNA-binding protein -
LNM86_RS03685 (LNM86_03685) 793865..795031 - 1167 WP_241438481.1 site-specific integrase -
LNM86_RS03690 (LNM86_03690) 795307..796206 + 900 WP_241438482.1 hypothetical protein -
LNM86_RS03695 (LNM86_03695) 796300..797430 + 1131 WP_241438483.1 N4-gp56 family major capsid protein -
LNM86_RS03700 (LNM86_03700) 797448..797828 + 381 WP_241438484.1 hypothetical protein -
LNM86_RS03705 (LNM86_03705) 797841..798221 + 381 WP_241438485.1 hypothetical protein -
LNM86_RS03710 (LNM86_03710) 798257..798538 - 282 WP_241438486.1 putative addiction module antidote protein Antitoxin
LNM86_RS03715 (LNM86_03715) 798519..798830 - 312 WP_241438487.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LNM86_RS03720 (LNM86_03720) 798894..799088 + 195 Protein_731 hypothetical protein -
LNM86_RS03725 (LNM86_03725) 799255..800421 + 1167 WP_241437300.1 site-specific integrase -
LNM86_RS03730 (LNM86_03730) 800640..800846 + 207 WP_241437301.1 DNA-binding protein -
LNM86_RS03735 (LNM86_03735) 800946..801843 + 898 Protein_734 toprim domain-containing protein -
LNM86_RS03740 (LNM86_03740) 801848..803449 + 1602 WP_241438488.1 YfjI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 731159..862007 130848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-95)

Antitoxin

Uncharacterized protein HI1420

(2-89)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11744.71 Da        Isoelectric Point: 8.9050

>T224758 WP_241438487.1 NZ_CP087114:c798830-798519 [Bartonella machadoae]
MVAIIKTTDEFDEWLEKLKDRKAADIILARLHKIRSGLLGDVKFFHGIGELRIHYGAGYRIYFTQKGNKIIILLCGGDKS
TQSKDIQKALSLLEDLKNEIENL

Download         Length: 312 bp

>T224758 NZ_CP120426:c12229-11867 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10146.57 Da        Isoelectric Point: 9.8657

>AT224758 WP_241438486.1 NZ_CP087114:c798538-798257 [Bartonella machadoae]
MKLKTFNFEKHLTTPESQEVFLNEAFKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPRLSTLVAVL
SALNLQLSVQSTP

Download         Length: 282 bp

>AT224758 NZ_CP120426:c12396-12226 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References