224754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1291589..1292631 Replicon chromosome
Accession NZ_CP087111
Organism Pseudomonas palleroniana strain X49

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag LDL65_RS06060 Protein ID WP_244700515.1
Coordinates 1291589..1292164 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag LDL65_RS06065 Protein ID WP_244700517.1
Coordinates 1292161..1292631 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL65_RS06020 (LDL65_06020) 1286645..1287547 - 903 WP_090368689.1 HlyD family secretion protein -
LDL65_RS06025 (LDL65_06025) 1287559..1287747 - 189 WP_060754331.1 DUF1656 domain-containing protein -
LDL65_RS06030 (LDL65_06030) 1287890..1288690 + 801 WP_060754332.1 helix-turn-helix transcriptional regulator -
LDL65_RS06035 (LDL65_06035) 1288804..1289184 + 381 WP_060754333.1 cupin domain-containing protein -
LDL65_RS06040 (LDL65_06040) 1289374..1289703 + 330 WP_244700507.1 hypothetical protein -
LDL65_RS06045 (LDL65_06045) 1289728..1290363 - 636 WP_244700509.1 LysE family translocator -
LDL65_RS06050 (LDL65_06050) 1290531..1290902 + 372 WP_244700511.1 PH domain-containing protein -
LDL65_RS06055 (LDL65_06055) 1291024..1291518 + 495 WP_244700513.1 hypothetical protein -
LDL65_RS06060 (LDL65_06060) 1291589..1292164 - 576 WP_244700515.1 PIN domain-containing protein Toxin
LDL65_RS06065 (LDL65_06065) 1292161..1292631 - 471 WP_244700517.1 helix-turn-helix domain-containing protein Antitoxin
LDL65_RS06070 (LDL65_06070) 1292828..1293991 + 1164 WP_161550064.1 S-type pyocin domain-containing protein -
LDL65_RS06075 (LDL65_06075) 1294006..1294293 + 288 WP_161550063.1 colicin E3-like toxin immunity protein -
LDL65_RS06080 (LDL65_06080) 1294298..1294759 + 462 WP_244700518.1 hypothetical protein -
LDL65_RS06085 (LDL65_06085) 1294887..1296239 - 1353 WP_161550061.1 sensor histidine kinase -
LDL65_RS06090 (LDL65_06090) 1296236..1296898 - 663 WP_060754342.1 response regulator -
LDL65_RS06095 (LDL65_06095) 1297046..1297312 + 267 WP_060754343.1 PepSY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1276498..1294759 18261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21584.97 Da        Isoelectric Point: 5.0339

>T224754 WP_244700515.1 NZ_CP087111:c1292164-1291589 [Pseudomonas palleroniana]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTNQIHEEWKRNVLKNRPDLTVEQVNCTSALMDKAIPDALVTGY
EDLCSGLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPPHILAAYDIEPMHPDDFISDLWDLDQAAVLGAAQKQRRALKR
PPMEAGNYIEMLMRQGLVQTSKVLGPYEVML

Download         Length: 576 bp

>T224754 NZ_CP120425:805892-806080 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17485.12 Da        Isoelectric Point: 5.6324

>AT224754 WP_244700517.1 NZ_CP087111:c1292631-1292161 [Pseudomonas palleroniana]
MMTNHLPKTILPLEKEVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHTLVLPTSALRLLVDILGELAIGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMSFKQRRDEESQEAMEALAQQAQELGMGYDG

Download         Length: 471 bp

>AT224754 NZ_CP120425:805610-805867 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References