Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 439843..441382 Replicon chromosome
Accession NC_009831
Organism Shewanella sediminis HAW-EB3

Toxin (Protein)


Gene name hipA Uniprot ID A8FQ65
Locus tag SSED_RS01930 Protein ID WP_012140726.1
Coordinates 439843..441147 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SSED_RS01935 Protein ID WP_012140727.1
Coordinates 441134..441382 (-) Length 83 a.a.

Genomic Context

SSED_RS01910SSED_RS01915SSED_RS01920SSED_RS01945SSED_RS01950SSED_RS01925SSED_RS01930SSED_RS01935SSED_RS01940SSED_RS01955
Location: 435056..436882 (1827 bp)
Type: Others
Protein ID: WP_012140722.1
Location: 437011..438036 (1026 bp)
Type: Others
Protein ID: WP_012140723.1
Location: 438266..438928 (663 bp)
Type: Others
Protein ID: WP_012140724.1
Location: 442841..443554 (714 bp)
Type: Others
Protein ID: WP_012140729.1
Location: 443641..444282 (642 bp)
Type: Others
Protein ID: WP_012140730.1
Location: 439043..439681 (639 bp)
Type: Others
Protein ID: WP_012140725.1
Location: 439843..441147 (1305 bp)
Type: Toxin
Protein ID: WP_012140726.1
Location: 441134..441382 (249 bp)
Type: Antitoxin
Protein ID: WP_012140727.1
Location: 441797..442660 (864 bp)
Type: Others
Protein ID: WP_012140728.1
Location: 444582..445241 (660 bp)
Type: Others
Protein ID: WP_012140731.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SSED_RS01910435056..436882+1827WP_012140722.1hypothetical protein-
SSED_RS01915437011..438036+1026WP_012140723.1manganese-dependent inorganic pyrophosphatase-
SSED_RS01920438266..438928+663WP_012140724.1adenylate kinase-
SSED_RS01925439043..439681-639WP_012140725.1multidrug MFS transporter-
SSED_RS01930439843..441147-1305WP_012140726.1HipA domain-containing proteinToxin
SSED_RS01935441134..441382-249WP_012140727.1helix-turn-helix domain-containing proteinAntitoxin
SSED_RS01940441797..442660-864WP_012140728.1YicC family protein-
SSED_RS01945442841..443554+714WP_012140729.1ribonuclease PH-
SSED_RS01950443641..444282+642WP_012140730.1orotate phosphoribosyltransferase-
SSED_RS01955444582..445241-660WP_012140731.1GTP cyclohydrolase I FolE-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(13-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 49168.40 Da        Isoelectric Point: 5.7644

>T22473 WP_012140726.1 NC_009831:c441147-439843 [Shewanella sediminis HAW-EB3]
MSGSNFHILEMHFRGMVIGAIGFDIDTEQFSIEYTKPWQEKGFPISPRLPLDGQASSSQISIYLTNLLPENKGLDHLIEA
LGIAKSNTFGLIKGIGFDTSGAILYLPVGTKPPATSFTPICKEDLIKRIEDPEHWPMEVWDGKPRLSVAGVQSKLNLFHS
DKEYGFGEGELCSTHIIKFEKNNQHLVLNEFITMTLAGLIGMQVAKVDIMPIGKYKALSVTRFDRMYEPERHIVMRRHQI
DVCQALGFSVSRKYERNFGSGRDVQDIREGVSLERLFSIAEHCANPAQAKFDMLRWTIFNLLVCNADSHGKNYSFYVTPD
GLEPTPWYDLVNVQMYPDFDQELAMAIGDEFEADKIHAYQLMTFAEECGIKQNILELSLKQLAKAIIGNLDKAAKQTGEI
TDAESKYVETYKKTIQARCEYYLAQVEEMKHIKL

Download         Length: 1305 bp

>T22473 NC_009831:c441147-439843 [Shewanella sediminis HAW-EB3]
ATGAGTGGTTCTAACTTTCACATCCTAGAGATGCACTTTAGAGGCATGGTTATTGGGGCGATAGGTTTTGACATAGACAC
TGAACAGTTCTCTATCGAATACACTAAACCTTGGCAGGAAAAGGGCTTTCCAATTTCACCAAGGCTCCCACTTGATGGCC
AAGCCAGCAGTTCTCAAATTTCCATTTACCTGACTAACCTACTGCCCGAAAATAAAGGGCTTGATCACCTCATTGAAGCC
CTAGGCATTGCCAAAAGTAATACATTTGGTCTGATCAAGGGCATTGGGTTTGATACCTCTGGTGCAATATTGTATCTGCC
TGTGGGCACCAAACCACCAGCAACCTCTTTTACTCCGATTTGCAAAGAAGACCTCATCAAACGAATCGAAGATCCTGAAC
ATTGGCCGATGGAAGTCTGGGACGGAAAACCACGCCTTTCAGTTGCTGGAGTTCAATCAAAATTAAACCTATTCCACAGC
GACAAAGAATACGGATTTGGTGAAGGTGAACTCTGCTCAACCCACATCATTAAATTTGAAAAAAACAATCAGCACCTCGT
ACTTAACGAATTTATTACCATGACACTTGCCGGCCTCATCGGCATGCAGGTTGCGAAAGTTGATATAATGCCAATAGGGA
AATACAAAGCATTATCCGTTACCCGCTTCGATCGCATGTACGAACCTGAGCGCCATATTGTAATGCGTCGTCACCAGATC
GATGTATGTCAGGCTCTGGGATTTTCCGTCTCAAGAAAGTATGAACGAAATTTTGGTAGTGGACGTGACGTTCAAGATAT
TCGTGAAGGAGTGAGTCTAGAAAGGCTGTTTAGCATCGCTGAGCACTGTGCTAATCCAGCACAAGCCAAGTTTGACATGC
TTCGTTGGACAATCTTTAACTTACTCGTCTGCAATGCGGACTCACATGGCAAAAACTATTCATTCTATGTAACTCCTGAT
GGGCTTGAACCGACCCCATGGTATGATCTTGTCAACGTGCAGATGTACCCTGATTTTGATCAAGAGCTTGCTATGGCTAT
TGGTGATGAGTTCGAAGCTGACAAGATCCACGCCTACCAATTGATGACATTTGCTGAAGAATGTGGAATTAAGCAAAACA
TACTTGAATTATCGCTCAAGCAACTGGCGAAAGCGATTATCGGCAATCTGGATAAAGCGGCAAAACAAACCGGGGAGATT
ACGGATGCAGAATCCAAGTATGTTGAGACGTACAAAAAAACCATTCAAGCACGATGTGAATACTACCTGGCTCAGGTTGA
AGAAATGAAACACATTAAGCTATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9146.64 Da        Isoelectric Point: 10.0606

>AT22473 WP_012140727.1 NC_009831:c441382-441134 [Shewanella sediminis HAW-EB3]
MLTQFDPNTLGKLIKDRRKAADMNQEIAASFCGVTKKTLIRVEKGEDVYFSTIIKILNGLGIKLTVETPNSKNKLGGSNE
WF

Download         Length: 249 bp

>AT22473 NC_009831:c441382-441134 [Shewanella sediminis HAW-EB3]
ATGCTCACTCAATTCGATCCAAACACCTTAGGCAAACTAATCAAAGACCGCCGAAAGGCCGCTGACATGAATCAGGAAAT
AGCCGCATCATTCTGTGGTGTTACCAAGAAGACCTTGATCAGAGTCGAAAAAGGCGAAGATGTGTACTTTTCAACGATAA
TCAAAATCCTCAATGGCCTTGGTATAAAGCTGACCGTCGAGACTCCTAATAGCAAAAACAAATTAGGTGGCAGCAATGAG
TGGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA8FQ65

Antitoxin

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Source
ID
Structure
No matching records found

References