Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 234215..234857 Replicon chromosome
Accession NZ_CP087103
Organism Bacillus toyonensis strain HA0190

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag HQN46_RS01330 Protein ID WP_000635963.1
Coordinates 234507..234857 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag HQN46_RS01325 Protein ID WP_000004570.1
Coordinates 234215..234502 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN46_RS01300 (HQN46_0001300) 229542..230504 + 963 WP_144467614.1 UV DNA damage repair endonuclease UvsE -
HQN46_RS01305 (HQN46_0001305) 230497..231069 - 573 WP_215712537.1 rhomboid family intramembrane serine protease -
HQN46_RS01310 (HQN46_0001310) 231162..231521 + 360 WP_016107395.1 holo-ACP synthase -
HQN46_RS01315 (HQN46_0001315) 231678..232628 + 951 WP_002059179.1 outer membrane lipoprotein carrier protein LolA -
HQN46_RS01320 (HQN46_0001320) 232746..233915 + 1170 WP_000390621.1 alanine racemase -
HQN46_RS01325 (HQN46_0001325) 234215..234502 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
HQN46_RS01330 (HQN46_0001330) 234507..234857 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
HQN46_RS01335 (HQN46_0001335) 234926..237094 + 2169 WP_000426216.1 Tex family protein -
HQN46_RS01340 (HQN46_0001340) 237152..237268 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
HQN46_RS01345 (HQN46_0001345) 237476..237934 + 459 WP_000544526.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T224719 WP_000635963.1 NZ_CP087103:234507-234857 [Bacillus toyonensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T224719 NZ_CP120397:c4596923-4596549 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT224719 WP_000004570.1 NZ_CP087103:234215-234502 [Bacillus toyonensis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT224719 NZ_CP120397:c4597165-4596923 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References