Detailed information of TA system TA224718

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-RelB
• Location: 33778..34282
• Replicon: plasmid pCEST-001A
• Accession: NZ_CP087099
• Organism: Clostridium estertheticum strain CEST001

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LOR37_RS21895
• Protein ID: WP_151553814.1
• Coordinates: 33778..34035 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOR37_RS21900
• Protein ID: WP_151553813.1
• Coordinates: 34028..34282 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOR37_RS21875 (LOR37_21785)	29501..30466	+	966	WP_171298639.1	ketopantoate reductase family protein	-
LOR37_RS21880 (LOR37_21790)	30583..32202	+	1620	WP_171298640.1	polysaccharide biosynthesis protein	-
LOR37_RS21885 (LOR37_21795)	32296..32847	+	552	WP_171298641.1	GNAT family N-acetyltransferase	-
LOR37_RS21890 (LOR37_21800)	33116..33508	+	393	WP_171298642.1	NUDIX domain-containing protein	-
LOR37_RS21895 (LOR37_21805)	33778..34035	-	258	WP_151553814.1	Txe/YoeB family addiction module toxin	Toxin
LOR37_RS21900 (LOR37_21810)	34028..34282	-	255	WP_151553813.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LOR37_RS21905 (LOR37_21815)	34444..35019	+	576	WP_171298643.1	hypothetical protein	-
LOR37_RS21910 (LOR37_21820)	35129..35707	-	579	WP_171298644.1	tyrosine-type recombinase/integrase	-
LOR37_RS21915 (LOR37_21825)	36225..36749	+	525	WP_171298645.1	hypothetical protein	-
LOR37_RS21920 (LOR37_21830)	36826..37347	+	522	WP_243177067.1	hypothetical protein	-
LOR37_RS21925 (LOR37_21835)	37947..38699	+	753	WP_151553786.1	ParA family protein	-
LOR37_RS21930 (LOR37_21840)	38692..39066	+	375	WP_152754036.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..209276	209276

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10206.55 Da
• Isoelectric Point: 6.9774

>T224718 WP_151553814.1 NZ_CP087099:c34035-33778 [Clostridium estertheticum]
MNKIFSEVSWEHYVYWQSEDKKILRKINELIKDIERNGNEGLGKPEALKHELVGYWSRRITDVHRLIYSIDDENIYVASC
KGHYH

Nucleotide

• Length: 258 bp

>T224718 NZ_CP120397:c4082329-4081841 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9805.16 Da
• Isoelectric Point: 5.1086

>AT224718 WP_151553813.1 NZ_CP087099:c34282-34028 [Clostridium estertheticum]
MIAIGYSNARQNFKNYCDKATKDFETIIITRERGDNVVMLSESAYNNLMENLYVRSDPTYYNELLKSIDQLKMGKGIRKE
LLDE

Nucleotide

• Length: 255 bp

>AT224718 NZ_CP120397:c4082619-4082326 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA