Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 11999..12611 Replicon plasmid P4
Accession NZ_CP087094
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-26

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE12_RS22730 Protein ID WP_028288627.1
Coordinates 12216..12611 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE12_RS22725 Protein ID WP_009503866.1
Coordinates 11999..12226 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE12_RS22710 (LOE12_22710) 8256..9467 - 1212 WP_050525470.1 plasmid replication protein RepC -
LOE12_RS22715 (LOE12_22715) 9681..10613 - 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE12_RS22720 (LOE12_22720) 10597..11790 - 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE12_RS22725 (LOE12_22725) 11999..12226 + 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE12_RS22730 (LOE12_22730) 12216..12611 + 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE12_RS22735 (LOE12_22735) 12690..13181 - 492 Protein_13 recombinase family protein -
LOE12_RS22740 (LOE12_22740) 13283..14434 - 1152 WP_224557873.1 tyrosine-type recombinase/integrase -
LOE12_RS22745 (LOE12_22745) 14549..15433 + 885 WP_037239259.1 DUF1403 family protein -
LOE12_RS22750 (LOE12_22750) 15481..16092 + 612 WP_197919471.1 SMC-Scp complex subunit ScpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110588 110588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224716 WP_028288627.1 NZ_CP087094:12216-12611 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224716 NZ_CP120397:c3862807-3862520 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224716 WP_009503866.1 NZ_CP087094:11999-12226 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224716 NZ_CP120397:c3862533-3862231 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References