Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 76496..77170 Replicon plasmid P3
Accession NZ_CP087093
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-26

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE12_RS21600 Protein ID WP_224557924.1
Coordinates 76748..77170 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE12_RS21595 Protein ID WP_229939240.1
Coordinates 76496..76744 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE12_RS21575 (LOE12_21575) 72409..73053 + 645 WP_224557929.1 type IV secretion system protein -
LOE12_RS21580 (LOE12_21580) 73057..73788 + 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE12_RS21585 (LOE12_21585) 73791..75248 + 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE12_RS21590 (LOE12_21590) 75359..76348 + 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE12_RS21595 (LOE12_21595) 76496..76744 + 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE12_RS21600 (LOE12_21600) 76748..77170 + 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE12_RS21605 (LOE12_21605) 77167..79917 + 2751 WP_224557923.1 lactate dehydrogenase -
LOE12_RS21610 (LOE12_21610) 79914..80972 + 1059 WP_224557922.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..290591 290591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224714 WP_224557924.1 NZ_CP087093:76748-77170 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224714 NZ_CP120397:c1368001-1367783 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224714 WP_229939240.1 NZ_CP087093:76496-76744 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224714 NZ_CP120397:c1368403-1368029 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References