Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2523565..2524145 Replicon chromosome
Accession NZ_CP087090
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-26

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE12_RS12675 Protein ID WP_224556587.1
Coordinates 2523891..2524145 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE12_RS12670 Protein ID WP_224556600.1
Coordinates 2523565..2523894 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE12_RS12615 (LOE12_12615) 2518637..2519527 + 891 WP_229940766.1 RNA ligase family protein -
LOE12_RS12620 (LOE12_12620) 2519527..2519715 + 189 WP_224556628.1 hypothetical protein -
LOE12_RS12625 (LOE12_12625) 2519712..2519870 + 159 WP_224556625.1 hypothetical protein -
LOE12_RS12630 (LOE12_12630) 2519867..2520121 + 255 WP_224556623.1 hypothetical protein -
LOE12_RS12635 (LOE12_12635) 2520118..2520423 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE12_RS12640 (LOE12_12640) 2520420..2520836 + 417 WP_229940505.1 hypothetical protein -
LOE12_RS12645 (LOE12_12645) 2520833..2520997 + 165 WP_229940508.1 hypothetical protein -
LOE12_RS12650 (LOE12_12650) 2521119..2522042 + 924 WP_229940510.1 phage minor head protein -
LOE12_RS12655 (LOE12_12655) 2522262..2522786 + 525 WP_224556606.1 hypothetical protein -
LOE12_RS12660 (LOE12_12660) 2522849..2523139 + 291 WP_224556604.1 hypothetical protein -
LOE12_RS24535 2523132..2523254 + 123 WP_263481010.1 hypothetical protein -
LOE12_RS12665 (LOE12_12665) 2523241..2523504 - 264 WP_224556602.1 hypothetical protein -
LOE12_RS12670 (LOE12_12670) 2523565..2523894 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE12_RS12675 (LOE12_12675) 2523891..2524145 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE12_RS12680 (LOE12_12680) 2524257..2524445 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE12_RS12685 (LOE12_12685) 2524545..2524715 + 171 WP_224556583.1 hypothetical protein -
LOE12_RS12690 (LOE12_12690) 2524791..2525243 + 453 WP_224556581.1 hypothetical protein -
LOE12_RS12695 (LOE12_12695) 2525243..2525404 + 162 WP_224556578.1 hypothetical protein -
LOE12_RS12700 (LOE12_12700) 2525401..2526228 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE12_RS12705 (LOE12_12705) 2526206..2526721 + 516 WP_224556573.1 hypothetical protein -
LOE12_RS12710 (LOE12_12710) 2526799..2527122 - 324 WP_224556571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2505764..2542385 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224712 WP_224556587.1 NZ_CP087090:c2524145-2523891 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224712 NZ_CP120397:799843-800241 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224712 WP_224556600.1 NZ_CP087090:c2523894-2523565 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224712 NZ_CP120397:799616-799843 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References