Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 276245..276919 Replicon plasmid P1
Accession NZ_CP087084
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE33_RS20605 Protein ID WP_224557924.1
Coordinates 276245..276667 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE33_RS20610 Protein ID WP_229939240.1
Coordinates 276671..276919 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE33_RS20595 (LOE33_20565) 272443..273501 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE33_RS20600 (LOE33_20570) 273498..276248 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE33_RS20605 (LOE33_20575) 276245..276667 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE33_RS20610 (LOE33_20580) 276671..276919 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE33_RS20615 (LOE33_20585) 277067..278056 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE33_RS20620 (LOE33_20590) 278167..279624 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE33_RS20625 (LOE33_20595) 279627..280358 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE33_RS20630 (LOE33_20600) 280362..281006 - 645 WP_224557929.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..290593 290593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224707 WP_224557924.1 NZ_CP087084:c276667-276245 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224707 NZ_CP120396:4598883-4599194 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224707 WP_229939240.1 NZ_CP087084:c276919-276671 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224707 NZ_CP120396:4599191-4599637 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References