Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3778252..3778832 Replicon chromosome
Accession NZ_CP087083
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE33_RS18830 Protein ID WP_224556587.1
Coordinates 3778252..3778506 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE33_RS18835 Protein ID WP_224556600.1
Coordinates 3778503..3778832 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE33_RS18795 (LOE33_18775) 3775275..3775598 + 324 WP_224556571.1 hypothetical protein -
LOE33_RS18800 (LOE33_18780) 3775676..3776191 - 516 WP_224556573.1 hypothetical protein -
LOE33_RS18805 (LOE33_18785) 3776169..3776996 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE33_RS18810 (LOE33_18790) 3776993..3777154 - 162 WP_224556578.1 hypothetical protein -
LOE33_RS18815 (LOE33_18795) 3777154..3777606 - 453 WP_224556581.1 hypothetical protein -
LOE33_RS18820 (LOE33_18800) 3777682..3777852 - 171 WP_224556583.1 hypothetical protein -
LOE33_RS18825 (LOE33_18805) 3777952..3778140 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE33_RS18830 (LOE33_18810) 3778252..3778506 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE33_RS18835 (LOE33_18815) 3778503..3778832 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE33_RS18840 (LOE33_18820) 3778893..3779156 + 264 WP_224556602.1 hypothetical protein -
LOE33_RS24835 3779143..3779265 - 123 WP_263481010.1 hypothetical protein -
LOE33_RS18845 (LOE33_18825) 3779258..3779548 - 291 WP_224556604.1 hypothetical protein -
LOE33_RS18850 (LOE33_18830) 3779611..3780135 - 525 WP_224556606.1 hypothetical protein -
LOE33_RS18855 (LOE33_18835) 3780355..3781278 - 924 WP_229940510.1 phage minor head protein -
LOE33_RS18860 (LOE33_18840) 3781400..3781564 - 165 WP_229940508.1 hypothetical protein -
LOE33_RS18865 (LOE33_18845) 3781561..3781977 - 417 WP_229940505.1 hypothetical protein -
LOE33_RS18870 (LOE33_18850) 3781974..3782279 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE33_RS18875 (LOE33_18855) 3782276..3782530 - 255 WP_224556623.1 hypothetical protein -
LOE33_RS18880 (LOE33_18860) 3782527..3782685 - 159 WP_224556625.1 hypothetical protein -
LOE33_RS18885 (LOE33_18865) 3782682..3782870 - 189 WP_224556628.1 hypothetical protein -
LOE33_RS18890 (LOE33_18870) 3782870..3783757 - 888 WP_224556631.1 RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3760560..3798073 37513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224705 WP_224556587.1 NZ_CP087083:3778252-3778506 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224705 NZ_CP120396:c4082827-4082339 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224705 WP_224556600.1 NZ_CP087083:3778503-3778832 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224705 NZ_CP120396:c4083117-4082824 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References