Detailed information of TA system TA224702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 63980..64541
• Replicon: plasmid P8
• Accession: NZ_CP087080
• Organism: Pseudosulfitobacter pseudonitzschiae strain MC36-14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOE32_RS24565
• Protein ID: WP_224557555.1
• Coordinates: 64266..64541 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOE32_RS24560
• Protein ID: WP_224557554.1
• Coordinates: 63980..64273 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE32_RS24545 (LOE32_24535)	59457..60992	-	1536	WP_224557548.1	aldehyde dehydrogenase (NADP(+))	-
LOE32_RS24550 (LOE32_24540)	61254..62993	+	1740	WP_224557550.1	L-arabinonate dehydratase	-
LOE32_RS24555 (LOE32_24545)	63004..63909	+	906	WP_224557552.1	dihydrodipicolinate synthase family protein	-
LOE32_RS24560 (LOE32_24550)	63980..64273	+	294	WP_224557554.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOE32_RS24565 (LOE32_24555)	64266..64541	+	276	WP_224557555.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOE32_RS24570 (LOE32_24560)	65010..65780	-	771	WP_224557557.1	GntR family transcriptional regulator	-
LOE32_RS24575 (LOE32_24565)	65872..67419	+	1548	WP_224557559.1	altronate dehydratase family protein	-
LOE32_RS24580 (LOE32_24570)	67436..68752	+	1317	WP_224557560.1	lactate racemase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..82230	82230

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10108.67 Da
• Isoelectric Point: 4.4912

>T224702 WP_224557555.1 NZ_CP087080:64266-64541 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Nucleotide

• Length: 276 bp

>T224702 NZ_CP120396:c2734584-2734482 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10166.59 Da
• Isoelectric Point: 7.2024

>AT224702 WP_224557554.1 NZ_CP087080:63980-64273 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Nucleotide

• Length: 294 bp

>AT224702 NZ_CP120396:2734480-2734623 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG