Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1335030..1335610 Replicon chromosome
Accession NZ_CP087073
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-14

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE32_RS07010 Protein ID WP_224556587.1
Coordinates 1335356..1335610 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE32_RS07005 Protein ID WP_224556600.1
Coordinates 1335030..1335359 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE32_RS06960 (LOE32_06965) 1330067..1330702 - 636 WP_224556647.1 S24 family peptidase -
LOE32_RS06965 (LOE32_06970) 1330789..1330989 + 201 WP_229940767.1 hypothetical protein -
LOE32_RS06970 (LOE32_06975) 1330986..1331654 + 669 WP_224556642.1 hypothetical protein -
LOE32_RS06975 (LOE32_06980) 1331658..1332089 + 432 WP_224556641.1 hypothetical protein -
LOE32_RS06980 (LOE32_06985) 1332177..1332647 + 471 WP_229944644.1 hypothetical protein -
LOE32_RS06985 (LOE32_06990) 1332584..1333507 + 924 WP_229940510.1 phage minor head protein -
LOE32_RS06990 (LOE32_06995) 1333727..1334251 + 525 WP_224556606.1 hypothetical protein -
LOE32_RS06995 (LOE32_07000) 1334314..1334604 + 291 WP_224556604.1 hypothetical protein -
LOE32_RS07000 (LOE32_07005) 1334706..1334969 - 264 WP_224556602.1 hypothetical protein -
LOE32_RS07005 (LOE32_07010) 1335030..1335359 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE32_RS07010 (LOE32_07015) 1335356..1335610 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE32_RS07015 (LOE32_07020) 1335722..1335910 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE32_RS07020 (LOE32_07025) 1336010..1336180 + 171 WP_224556583.1 hypothetical protein -
LOE32_RS07025 (LOE32_07030) 1336256..1336708 + 453 WP_224556581.1 hypothetical protein -
LOE32_RS07030 (LOE32_07035) 1336708..1336869 + 162 WP_224556578.1 hypothetical protein -
LOE32_RS07035 (LOE32_07040) 1336866..1337693 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE32_RS07040 (LOE32_07045) 1337671..1338186 + 516 WP_224556573.1 hypothetical protein -
LOE32_RS07045 (LOE32_07050) 1338264..1338641 - 378 WP_229940765.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1321704..1353850 32146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224696 WP_224556587.1 NZ_CP087073:c1335610-1335356 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224696 NZ_CP120396:641612-642103 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGTGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224696 WP_224556600.1 NZ_CP087073:c1335359-1335030 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224696 NZ_CP120396:641322-641615 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGTGAAACTCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGTTGGAAGCTGCCCGTGCTGCCGCAGAAGAAGTGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References