Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4787705..4788300 Replicon chromosome
Accession NC_009801
Organism Escherichia coli E24377A

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag ECE24377A_RS25385 Protein ID WP_000239579.1
Coordinates 4787950..4788300 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag ECE24377A_RS25380 Protein ID WP_001223208.1
Coordinates 4787705..4787956 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECE24377A_RS25370 4783370..4787149 + 3780 WP_000060927.1 autotransporter assembly complex protein TamB -
ECE24377A_RS25375 4787152..4787493 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ECE24377A_RS25380 4787705..4787956 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ECE24377A_RS25385 4787950..4788300 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
ECE24377A_RS25390 4788380..4788910 - 531 WP_000055072.1 inorganic diphosphatase -
ECE24377A_RS25395 4789220..4790176 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ECE24377A_RS25400 4790316..4791818 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
ECE24377A_RS25405 4791832..4792854 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T22469 WP_000239579.1 NC_009801:4787950-4788300 [Escherichia coli O139:H28 str. E24377A]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T22469 NC_009801:4787950-4788300 [Escherichia coli O139:H28 str. E24377A]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTTGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT22469 WP_001223208.1 NC_009801:4787705-4787956 [Escherichia coli O139:H28 str. E24377A]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT22469 NC_009801:4787705-4787956 [Escherichia coli O139:H28 str. E24377A]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References