Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1337348..1337928 Replicon chromosome
Accession NZ_CP087066
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-22

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE34_RS06650 Protein ID WP_224556587.1
Coordinates 1337348..1337602 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE34_RS06655 Protein ID WP_224556600.1
Coordinates 1337599..1337928 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE34_RS06615 (LOE34_06610) 1334317..1334694 + 378 WP_229940765.1 hypothetical protein -
LOE34_RS06620 (LOE34_06615) 1334772..1335287 - 516 WP_224556573.1 hypothetical protein -
LOE34_RS06625 (LOE34_06620) 1335265..1336092 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE34_RS06630 (LOE34_06625) 1336089..1336250 - 162 WP_224556578.1 hypothetical protein -
LOE34_RS06635 (LOE34_06630) 1336250..1336702 - 453 WP_224556581.1 hypothetical protein -
LOE34_RS06640 (LOE34_06635) 1336778..1336948 - 171 WP_224556583.1 hypothetical protein -
LOE34_RS06645 (LOE34_06640) 1337048..1337236 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE34_RS06650 (LOE34_06645) 1337348..1337602 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE34_RS06655 (LOE34_06650) 1337599..1337928 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE34_RS06660 (LOE34_06655) 1337989..1338252 + 264 WP_224556602.1 hypothetical protein -
LOE34_RS06665 (LOE34_06660) 1338354..1338644 - 291 WP_224556604.1 hypothetical protein -
LOE34_RS06670 (LOE34_06665) 1338707..1339231 - 525 WP_224556606.1 hypothetical protein -
LOE34_RS06675 (LOE34_06670) 1339451..1340374 - 924 WP_229940510.1 phage minor head protein -
LOE34_RS06680 (LOE34_06675) 1340311..1340781 - 471 WP_229944644.1 hypothetical protein -
LOE34_RS06685 (LOE34_06680) 1340869..1341300 - 432 WP_224556641.1 hypothetical protein -
LOE34_RS06690 (LOE34_06685) 1341304..1341972 - 669 WP_224556642.1 hypothetical protein -
LOE34_RS06695 (LOE34_06690) 1341969..1342175 - 207 WP_229940501.1 hypothetical protein -
LOE34_RS06700 (LOE34_06695) 1342256..1342891 + 636 WP_224556647.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224689 WP_224556587.1 NZ_CP087066:1337348-1337602 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224689 NZ_CP120395:c3903789-3903502 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224689 WP_224556600.1 NZ_CP087066:1337599-1337928 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224689 NZ_CP120395:c3903515-3903213 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References