Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 60483..61044 | Replicon | plasmid P6 |
| Accession | NZ_CP087065 | ||
| Organism | Pseudosulfitobacter pseudonitzschiae strain MC36-24 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | LOE35_RS23600 | Protein ID | WP_224557555.1 |
| Coordinates | 60483..60758 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | LOE35_RS23605 | Protein ID | WP_224557554.1 |
| Coordinates | 60751..61044 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOE35_RS23585 (LOE35_23600) | 56272..57588 | - | 1317 | WP_224557560.1 | lactate racemase domain-containing protein | - |
| LOE35_RS23590 (LOE35_23605) | 57605..59152 | - | 1548 | WP_224557559.1 | altronate dehydratase family protein | - |
| LOE35_RS23595 (LOE35_23610) | 59244..60014 | + | 771 | WP_224557557.1 | GntR family transcriptional regulator | - |
| LOE35_RS23600 (LOE35_23615) | 60483..60758 | - | 276 | WP_224557555.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LOE35_RS23605 (LOE35_23620) | 60751..61044 | - | 294 | WP_224557554.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LOE35_RS23610 (LOE35_23625) | 61115..62020 | - | 906 | WP_224557552.1 | dihydrodipicolinate synthase family protein | - |
| LOE35_RS23615 (LOE35_23630) | 62031..63770 | - | 1740 | WP_224557550.1 | L-arabinonate dehydratase | - |
| LOE35_RS23620 (LOE35_23635) | 64032..65567 | + | 1536 | WP_224557548.1 | aldehyde dehydrogenase (NADP(+)) | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..82447 | 82447 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10108.67 Da Isoelectric Point: 4.4912
>T224688 WP_224557555.1 NZ_CP087065:c60758-60483 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP
Download Length: 276 bp
>T224688 NZ_CP120395:c2773983-2773881 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 98 a.a. Molecular weight: 10166.59 Da Isoelectric Point: 7.2024
>AT224688 WP_224557554.1 NZ_CP087065:c61044-60751 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA
Download Length: 294 bp
>AT224688 NZ_CP120395:2773879-2774022 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|