Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2022327..2022907 Replicon chromosome
Accession NZ_CP087059
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-24

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE35_RS10350 Protein ID WP_224556587.1
Coordinates 2022653..2022907 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE35_RS10345 Protein ID WP_224556600.1
Coordinates 2022327..2022656 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE35_RS10290 (LOE35_10295) 2017402..2018289 + 888 WP_224556631.1 RNA ligase family protein -
LOE35_RS10295 (LOE35_10300) 2018289..2018477 + 189 WP_224556628.1 hypothetical protein -
LOE35_RS10300 (LOE35_10305) 2018474..2018632 + 159 WP_224556625.1 hypothetical protein -
LOE35_RS10305 (LOE35_10310) 2018629..2018883 + 255 WP_224556623.1 hypothetical protein -
LOE35_RS10310 (LOE35_10315) 2018880..2019185 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE35_RS10315 (LOE35_10320) 2019182..2019598 + 417 WP_229940505.1 hypothetical protein -
LOE35_RS10320 (LOE35_10325) 2019595..2019759 + 165 WP_229940508.1 hypothetical protein -
LOE35_RS10325 (LOE35_10330) 2019881..2020804 + 924 WP_229940510.1 phage minor head protein -
LOE35_RS10330 (LOE35_10335) 2021024..2021548 + 525 WP_224556606.1 hypothetical protein -
LOE35_RS10335 (LOE35_10340) 2021611..2021901 + 291 WP_224556604.1 hypothetical protein -
LOE35_RS23730 2021894..2022016 + 123 WP_263481010.1 hypothetical protein -
LOE35_RS10340 (LOE35_10345) 2022003..2022266 - 264 WP_224556602.1 hypothetical protein -
LOE35_RS10345 (LOE35_10350) 2022327..2022656 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE35_RS10350 (LOE35_10355) 2022653..2022907 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE35_RS10355 (LOE35_10360) 2023019..2023207 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE35_RS10360 (LOE35_10365) 2023307..2023477 + 171 WP_224556583.1 hypothetical protein -
LOE35_RS10365 (LOE35_10370) 2023553..2024005 + 453 WP_224556581.1 hypothetical protein -
LOE35_RS10370 (LOE35_10375) 2024005..2024166 + 162 WP_224556578.1 hypothetical protein -
LOE35_RS10375 (LOE35_10380) 2024163..2024990 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE35_RS10380 (LOE35_10385) 2024968..2025483 + 516 WP_224556573.1 hypothetical protein -
LOE35_RS10385 (LOE35_10390) 2025561..2025884 - 324 WP_224556571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2004526..2041147 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224685 WP_224556587.1 NZ_CP087059:c2022907-2022653 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224685 NZ_CP120395:836458-836856 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224685 WP_224556600.1 NZ_CP087059:c2022656-2022327 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224685 NZ_CP120395:836231-836458 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References