Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 135899..136573 Replicon plasmid P3
Accession NZ_CP087054
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-43

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE36_RS20955 Protein ID WP_224557924.1
Coordinates 135899..136321 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE36_RS20960 Protein ID WP_229939240.1
Coordinates 136325..136573 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE36_RS20945 (LOE36_20965) 132097..133155 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE36_RS20950 (LOE36_20970) 133152..135902 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE36_RS20955 (LOE36_20975) 135899..136321 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE36_RS20960 (LOE36_20980) 136325..136573 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE36_RS20965 (LOE36_20985) 136721..137710 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE36_RS20970 (LOE36_20990) 137821..139278 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE36_RS20975 (LOE36_20995) 139281..140012 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE36_RS20980 (LOE36_21000) 140016..140660 - 645 WP_224557929.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..290596 290596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224681 WP_224557924.1 NZ_CP087054:c136321-135899 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224681 NZ_CP120394:c4636534-4636160 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224681 WP_229939240.1 NZ_CP087054:c136573-136325 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224681 NZ_CP120394:c4636776-4636534 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References