Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2022333..2022913 Replicon chromosome
Accession NZ_CP087051
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-43

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE36_RS10345 Protein ID WP_224556587.1
Coordinates 2022659..2022913 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE36_RS10340 Protein ID WP_224556600.1
Coordinates 2022333..2022662 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE36_RS10285 (LOE36_10280) 2017405..2018295 + 891 WP_229940766.1 RNA ligase family protein -
LOE36_RS10290 (LOE36_10285) 2018295..2018483 + 189 WP_224556628.1 hypothetical protein -
LOE36_RS10295 (LOE36_10290) 2018480..2018638 + 159 WP_224556625.1 hypothetical protein -
LOE36_RS10300 (LOE36_10295) 2018635..2018889 + 255 WP_224556623.1 hypothetical protein -
LOE36_RS10305 (LOE36_10300) 2018886..2019191 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE36_RS10310 (LOE36_10305) 2019188..2019604 + 417 WP_229940505.1 hypothetical protein -
LOE36_RS10315 (LOE36_10310) 2019601..2019765 + 165 WP_229940508.1 hypothetical protein -
LOE36_RS10320 (LOE36_10315) 2019887..2020810 + 924 WP_229940510.1 phage minor head protein -
LOE36_RS10325 (LOE36_10320) 2021030..2021554 + 525 WP_224556606.1 hypothetical protein -
LOE36_RS10330 (LOE36_10325) 2021617..2021907 + 291 WP_224556604.1 hypothetical protein -
LOE36_RS10335 (LOE36_10330) 2022009..2022272 - 264 WP_224556602.1 hypothetical protein -
LOE36_RS10340 (LOE36_10335) 2022333..2022662 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE36_RS10345 (LOE36_10340) 2022659..2022913 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE36_RS10350 (LOE36_10345) 2023025..2023213 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE36_RS10355 (LOE36_10350) 2023313..2023483 + 171 WP_224556583.1 hypothetical protein -
LOE36_RS10360 (LOE36_10355) 2023559..2024011 + 453 WP_224556581.1 hypothetical protein -
LOE36_RS10365 (LOE36_10360) 2024011..2024172 + 162 WP_224556578.1 hypothetical protein -
LOE36_RS10370 (LOE36_10365) 2024169..2024996 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE36_RS10375 (LOE36_10370) 2024974..2025489 + 516 WP_224556573.1 hypothetical protein -
LOE36_RS10380 (LOE36_10375) 2025567..2025944 - 378 WP_229940765.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2004532..2040691 36159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224678 WP_224556587.1 NZ_CP087051:c2022913-2022659 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224678 NZ_CP120394:c4009003-4008719 [Salmonella enterica subsp. enterica serovar Typhi]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224678 WP_224556600.1 NZ_CP087051:c2022662-2022333 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224678 NZ_CP120394:c4009235-4008993 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References