Detailed information of TA system TA224676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2786..3347
• Replicon: plasmid P8
• Accession: NZ_CP087050
• Organism: Pseudosulfitobacter pseudonitzschiae strain MC52-18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOE42_RS24160
• Protein ID: WP_224557555.1
• Coordinates: 3072..3347 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOE42_RS24155
• Protein ID: WP_224557554.1
• Coordinates: 2786..3079 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE42_RS24145 (LOE42_24140)	60..1799	+	1740	WP_224557550.1	L-arabinonate dehydratase	-
LOE42_RS24150 (LOE42_24145)	1810..2715	+	906	WP_224557552.1	dihydrodipicolinate synthase family protein	-
LOE42_RS24155 (LOE42_24150)	2786..3079	+	294	WP_224557554.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOE42_RS24160 (LOE42_24155)	3072..3347	+	276	WP_224557555.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOE42_RS24165 (LOE42_24160)	3816..4586	-	771	WP_224557557.1	GntR family transcriptional regulator	-
LOE42_RS24170 (LOE42_24165)	4678..6225	+	1548	WP_224557559.1	altronate dehydratase family protein	-
LOE42_RS24175 (LOE42_24170)	6242..7558	+	1317	WP_224557560.1	lactate racemase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..82230	82230

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10108.67 Da
• Isoelectric Point: 4.4912

>T224676 WP_224557555.1 NZ_CP087050:3072-3347 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Nucleotide

• Length: 276 bp

>T224676 NZ_CP120394:c2756883-2756781 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10166.59 Da
• Isoelectric Point: 7.2024

>AT224676 WP_224557554.1 NZ_CP087050:2786-3079 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Nucleotide

• Length: 294 bp

>AT224676 NZ_CP120394:2756779-2756922 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG