Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 2461262..2461727 Replicon chromosome
Accession NZ_CP087042
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-18

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE42_RS12575 Protein ID WP_224557762.1
Coordinates 2461262..2461525 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE42_RS12580 Protein ID WP_224557764.1
Coordinates 2461512..2461727 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE42_RS12550 (LOE42_12550) 2456978..2458528 - 1551 WP_224557015.1 restriction endonuclease subunit S -
LOE42_RS12555 (LOE42_12555) 2458525..2458821 - 297 WP_224557153.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
LOE42_RS12560 (LOE42_12560) 2458715..2459203 - 489 WP_229938596.1 DEAD/DEAH box helicase family protein -
LOE42_RS12565 (LOE42_12565) 2459429..2460538 - 1110 WP_224558030.1 IS110 family transposase -
LOE42_RS12570 (LOE42_12570) 2460631..2461074 - 444 WP_224557760.1 hypothetical protein -
LOE42_RS12575 (LOE42_12575) 2461262..2461525 + 264 WP_224557762.1 BrnT family toxin Toxin
LOE42_RS12580 (LOE42_12580) 2461512..2461727 + 216 WP_224557764.1 CopG family antitoxin Antitoxin
LOE42_RS12585 (LOE42_12585) 2462080..2462304 - 225 WP_224557765.1 hypothetical protein -
LOE42_RS12590 (LOE42_12590) 2462472..2462852 - 381 WP_224557766.1 helix-turn-helix domain-containing protein -
LOE42_RS12595 (LOE42_12595) 2463033..2464004 - 972 WP_224557767.1 hypothetical protein -
LOE42_RS12600 (LOE42_12600) 2463997..2465181 - 1185 WP_224557768.1 site-specific integrase -
LOE42_RS12610 (LOE42_12610) 2465559..2466257 - 699 WP_037931342.1 SURF1 family protein -
LOE42_RS12615 (LOE42_12615) 2466254..2466619 - 366 WP_028957811.1 cytochrome o ubiquinol oxidase subunit IV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2452881..2465181 12300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10254.52 Da        Isoelectric Point: 5.6550

>T224671 WP_224557762.1 NZ_CP087042:2461262-2461525 [Pseudosulfitobacter pseudonitzschiae]
MKFEYDPDKSAGNKAKHGIDFDEAQALWEDPWLLEAPARTDDEPRFFAIGMIKERHWSAVCTYRGDIIRIISVRRARKQE
IEHYEST

Download         Length: 264 bp

>T224671 NZ_CP120394:205083-205568 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGACGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8265.40 Da        Isoelectric Point: 10.6538

>AT224671 WP_224557764.1 NZ_CP087042:2461512-2461727 [Pseudosulfitobacter pseudonitzschiae]
MKAREFDQKFDTGENVSDLVDWSKARRTNTQTKRVNVDFPSWVVSGLDQKAKQLGVTRQSLIKLWIAERLQ

Download         Length: 216 bp

>AT224671 NZ_CP120394:204808-205095 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References